Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats

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dc.authoridAKAN, PINAR/0000-0001-9211-1944
dc.authoridAkturk, Gozde/0000-0003-1343-4361
dc.authoridHOCAOGLU AKSAY, NIL/0000-0002-7449-6809
dc.authoridKalkan, Sule/0000-0002-0364-7390
dc.authoridGURSOY CALAN, OZLEM/0000-0002-1312-3777
dc.authoridergur, bekir/0000-0002-6448-2593
dc.authoridSahin, Orhan/0000-0003-1606-3164
dc.contributor.authorSahin, Orhan
dc.contributor.authorAkturk, Gozde
dc.contributor.authorMicili, Serap Cilaker
dc.contributor.authorDoruk, Ozlem Gursoy
dc.contributor.authorKarapinar, Fazilet
dc.contributor.authorHocaoglu, Nil
dc.contributor.authorErgur, Bekir Ugur
dc.date.accessioned2024-09-18T19:54:16Z
dc.date.available2024-09-18T19:54:16Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives The aim of this study is to evaluate the protective effect of nicorandil, a selective mitochondrial K-ATP channel opener, on QT prolongation and myocardial damage induced by amitriptyline. Methods The dose of amitriptyline (intraperitoneal, i.p.) that prolong the QT interval was found 75 mg/kg. Rats were randomized into five groups the control group, amitriptyline group, nicorandil (selective mitochondrial K-ATP channel opener, 3 mg/kg i.p.) + amitriptyline group, 5-hdyroxydecanoate (5-HD, selective mitochondrial K-ATP channel blocker, 10 mg/kg i.p.) + amitriptyline group and 5-HD + nicorandil + amitriptyline group. Cardiac parameters, biochemical and histomorphological/immunohistochemical examinations were evaluated. p < 0.05 was accepted as statistically significant. Key findings Amitriptyline caused statistically significant prolongation of QRS duration, QT interval and QTc interval (p < 0.05). It also caused changes in tissue oxidant (increase in malondialdehyde)/anti-oxidant (decrease in glutathione peroxidase) parameters (p < 0.05), myocardial damage and apoptosis (p < 0.01 and p < 0.001). While nicorandil administration prevented amitriptyline-induced QRS, QT, QTc prolongation (p < 0.05), myocardial damage and apoptosis (p < 0.05), it did not affect the changes in oxidative parameters (p > 0.05). Conclusions Our results suggest that nicorandil, a selective mitochondrial K-ATP channel opener, plays a protective role in amitriptyline-induced QT prolongation and myocardial damage. Mitochondrial K-ATP channel opening and anti-apoptotic effects may play a role in the cardioprotective effect of nicorandil.en_US
dc.identifier.doi10.1093/jpp/rgac089
dc.identifier.endpage426en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158
dc.identifier.issue3en_US
dc.identifier.pmid36527252en_US
dc.identifier.scopus2-s2.0-85150079473en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1093/jpp/rgac089
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7615
dc.identifier.volume75en_US
dc.identifier.wosWOS:000898595600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamitriptylineen_US
dc.subjectnicorandilen_US
dc.subjectQT prolongationen_US
dc.subjectcardiotoxicityen_US
dc.subjectmitoK(ATP) channelen_US
dc.titleEffect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in ratsen_US
dc.typeArticleen_US

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