Effect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Rats

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dc.contributor.authorEvirgen, Omer
dc.contributor.authorGokce, Ahmet
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorNacar, Emel
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorOzer, Burcin
dc.contributor.authorMotor, Vicdan Koksaldi
dc.date.accessioned2024-09-18T20:28:18Z
dc.date.available2024-09-18T20:28:18Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: Recurrent urinary tract infections are important in children and adults with diabetes mellitus and/or incontinence due to risk of pyelonephritis (PYN) and renal damage. There is a positive correlation released free radicals during PYN and renal damage. Experimental studies showed that antioxidant agents improve renal damage when used immediately after bacterial inoculation. OBJECTIVE: The aim of the present study was to evaluate whether treatment by thymoquinone (TQ) before or during Escherichia coli inoculation prevents oxidative damage in acute pyelonephritis (PYN) in an ascending obstructive rat model. METHODS: In this study, 42 Wistar rats were grouped as follows: control, PYN (24, 48, and 72 hours), and TQ-PYN (24, 48, and 72 hours). E. coli (1 x 10(9) colony forming units) was inoculated into the bladder via urethral catheterization in both the PYN and TQ groups. TQ injections were performed 24 hours before bacteria inoculation and repeated at 24-hour intervals during the indicated time at a dose of 10 mg/kg body weight intraperitoneally in TQ groups. RESULTS: Superoxide dismutase activity was statistically lower in the TQ-PYN-48 and -72 groups than the PYN-48 and -72 groups (P < 0.001, P = 0.004, respectively). Catalase activity was significantly higher in PYN-24, -48, and -72 groups than the control group (P < 0.001). In addition, there was a significant difference between the TQ-PYN-24, -48, and -72 groups and PYN groups in terms of glutathione peroxidase activity (P < 0.001, P = 0.026, P = 0.046, respectively). When the TQ-PYN-72 group was compared with the PYN-72 group, malondialdehyde levels were significantly lower in the TQ-PYN-72 group than in the PYN-72 group (P = 0.033). A histologic examination also confirmed the protective effect of TQ. In statistical analysis of histopathologic findings, there were significant differences between the PYN-24 and TQ-PYN-24, PYN-48 and TQ-PYN-48, and PYN-72 and TQ-PYN-72 groups (P = 0.008, P < 0.001, P < 0.001, respectively). CONCLUSIONS: The results indicate that TQ administration attenuated the oxidative damage that occurred in PYN and, therefore, could be used as a supportive agent to protect the kidneys from oxidative damage caused by PYN. (Curr Ther Res Clin Exp. 2011;72:204-215) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.curtheres.2011.09.002
dc.identifier.endpage215en_US
dc.identifier.issn0011-393X
dc.identifier.issn1879-0313
dc.identifier.issue5en_US
dc.identifier.pmid24653507en_US
dc.identifier.scopus2-s2.0-80054016441en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2011.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10830
dc.identifier.volume72en_US
dc.identifier.wosWOS:000296211700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical and Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectkidneyen_US
dc.subjectoxidative stressen_US
dc.subjectpyelonephritisen_US
dc.subjectthymoquinoneen_US
dc.subjectWistar ratsen_US
dc.titleEffect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Ratsen_US
dc.typeArticleen_US

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