NEW FORMULATION EFFECTIVE AGAINST SARS CoV-2 AND H1N1
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Date
2022
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Inst. Nat. Cercetare-Dezvoltare Text. Pielarie
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info:eu-repo/semantics/openAccess
Abstract
People apply a wide variety of over-the-counter treatments as food supplements against respiratory tract infections. In this study, we investigated the antiviral efficacy of piperine, capsaicin, and glycyrrhetinic acid (GA) against coronaviruses (SARS-CoV-2) and Influenza viruses (H1N1), which are associated with acute respiratory infections. TCID50 concentrations of SARS-CoV-2 and H1N1 isolates were determined. Then, the effectiveness of phytochemicals against these viral isolates at non-toxic concentrations was investigated. For this purpose, the MTT method and RTPCR techniques were used. Non-toxic concentrations of Capsaicin, Piperine, and GA on Vero cells were determined as 0.625 ?g/ml, and Ceramide at 1.25 ?g/ml and lower concentrations. It was determined that Capsaicin and Piperine showed very significant antiviral activity against SARS CoV-2 when compared to standard drugs at concentrations of 0.312 ?g/ml. The effectiveness of GA was determined to be lower (0.625 ?g/ml) than these two phytochemicals. Capsaicin, piperine, and GA exhibited antiviral activity on SARS-CoV-2 and H1N1 viral replication, especially the activity of the combination of capsaicin plus piperine against SARS CoV-2 was stronger than the activity against N1N1 than against H1N1. In addition, it was determined that the triple combination of these components exhibited stronger antiviral activity than single and double combinations, resulting in a significant decrease in the number of viral copies. We think that this new formulation containing three different phytochemical compounds is effective against SARSCoV- 2 and influenza viruses, which are the most important causes of morbidity and mortality from respiratory tract viruses, and can be effective, especially for prophylactic purposes. © 2022 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.
Description
9th International Conference on Advanced Materials and Systems, ICAMS 2022 -- 26 October 2022 through 28 October 2022 -- Bucharest -- 292469
Keywords
influenza virus, phytochemicals, SARS CoV-2
Journal or Series
ICAMS Proceedings of the International Conference on Advanced Materials and Systems
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