Effectiveness of mesalamine and propolis in experimental colitis

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dc.authoridAban, Nedim/0009-0009-9204-7810
dc.contributor.authorAslan, Ahmet
dc.contributor.authorTemiz, Muhyittin
dc.contributor.authorAtik, Esin
dc.contributor.authorPolat, Gurbuz
dc.contributor.authorSahinler, Nuray
dc.contributor.authorBesirov, Eimir
dc.contributor.authorAban, Nedim
dc.date.accessioned2024-09-18T20:32:46Z
dc.date.available2024-09-18T20:32:46Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was conducted to investigate the effects of propolis and mesalamine on experimental colitis in rats. Distal colitis was induced in rats by intracolonic instillation of 2 mL of 4% acetic acid. The animals were randomly assigned to 5 groups: group 1, control, (n=8); group 2, colitis, received no treatment (n=8); group 3, colitis+mesalamine, 2 mL once a day via an enema (n=8); group 4, colitis+propolis, 600 mg/kg once a day via intragastric lavage (n=8); and group 5, colitis+ mesalamine+propolis for 1 wk (n=8). Levels of nitric oxide were statistically significantly different in comparisons between groups 1 and 2, groups 2 and 3, and groups 4 and 5. Malondialdehyde levels were significantly different when group 2 was compared with groups 3, 4, and 5. A significant difference was observed when group 3 was compared with group 4 for myeloperoxidase. Most propolis-treated rats had normal histology; mesalamine-treated and propolis+mesalamine-treated rats had inflammatory cell infiltration at rates of 50% and 33%, respectively. The investigators concluded that propolis and mesalamine are efficient independently and in combination, but that their combined effect was not observed to be additive in experimental colitis.en_US
dc.identifier.doi10.1007/BF02877715
dc.identifier.endpage1097en_US
dc.identifier.issn0741-238X
dc.identifier.issn1865-8652
dc.identifier.issue5en_US
dc.identifier.pmid18029336en_US
dc.identifier.scopus2-s2.0-37249016965en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1085en_US
dc.identifier.urihttps://doi.org/10.1007/BF02877715
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11098
dc.identifier.volume24en_US
dc.identifier.wosWOS:000251636700018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmesalamineen_US
dc.subjectpropolisen_US
dc.subjectexperimental colitisen_US
dc.titleEffectiveness of mesalamine and propolis in experimental colitisen_US
dc.typeArticleen_US

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