Circadian intraocular pressure control with dorzolamide versus timolol maleate add-on treatments in primary open-angle glaucoma patients using latanoprost

Basit Öğe Kaydı
dc.contributor.authorTamer, Cengaver
dc.contributor.authorOksuz, Huseyin
dc.date.accessioned2024-09-18T20:11:27Z
dc.date.available2024-09-18T20:11:27Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To compare the 24- hour efficacy of dorzolamide and timolol maleate administered twice daily to primary open-angle glaucoma patients whose intraocular pressure ( IOP) could not be adequately controlled with latanoprost monotherapy. Methods: In this double- blind prospective crossover clinical comparison trial, 36 primary open- angle glaucoma patients with uncontrolled IOP despite treatment with latanoprost applied once daily were administered timolol and dorzolamide twice daily. The treatment sequence was randomized. All patients underwent measurements for four 24- hour tonometric curves: at baseline and after each 4- week period of treatment. The IOP measurements were taken at 06: 00, 09: 00, 12: 00, 15: 00, 18: 00, 21: 00, 24: 00 and 03: 00 h. The between- group differences were tested for significance by means of parametric analysis of variance at each time point and circadian curve. The peak values within circadian curve were defined. The mean of the exact amount and percentage of additional IOP reductions from baseline were evaluated and success rates ( a minimum of 10% reduction) were determined for both drug regimens. Results: The mean peak/ circadian curve IOPs were 23.4 +/- 8 2.2/ 21.8 +/- 8 2.2 mm Hg at dorzolamide baseline, 23.3 +/- 8 2.2/ 21.7 +/- 8 2.1 mm Hg at timolol baseline, and reduced to 20.2 +/- 8 1.7/ 18.7 +/- 8 1.7 mm Hg and 20.7 +/- 8 2.4/ 19.4 +/- 8 1.6 mm Hg, respectively. When added to latanoprost, both dorzolamide and timolol lowered IOP at circadian curve significantly ( p < 0.05). Dorzolamide reduced baseline IOP values at each time point. Timolol also significantly reduced baseline IOP values at all time points except at 03:00. The mean of the exact amount and percentage of reduction in IOP at circadian curve and 5 out of 8 time points were significantly greater with dorzolamide add-on treatment ( p < 0.05). The successful reduction rates were 86% for the dorzolamide group and 61% for the timolol group ( p = 0.016; chi(2) 2 test). Conclusion: Both of the combinations are effective in lowering IOP, the exact amount and percentage of reduction is greater with the latanoprost + dorzolamide regimen, especially at night- time. Copyright (c) 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000097903
dc.identifier.endpage31en_US
dc.identifier.issn0030-3747
dc.identifier.issue1en_US
dc.identifier.pmid17164574en_US
dc.identifier.scopus2-s2.0-33846205180en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1159/000097903
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8853
dc.identifier.volume39en_US
dc.identifier.wosWOS:000243063900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcircadian intraocular pressureen_US
dc.subjectlatanoprosten_US
dc.subjecttimolol maleateen_US
dc.subjectdorzolamideen_US
dc.titleCircadian intraocular pressure control with dorzolamide versus timolol maleate add-on treatments in primary open-angle glaucoma patients using latanoprosten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
8853.pdf
Boyut:
217.97 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu