The importance of proliferative activity and angiogenesis in meningioma and glioma

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dc.authorscopusid36876295100
dc.authorscopusid15823044400
dc.authorscopusid55988818100
dc.authorscopusid6507829293
dc.contributor.authorAtik, Esin
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorBakariş, Sevgi
dc.contributor.authorSavaş, Nazan
dc.date.accessioned2024-09-19T15:43:30Z
dc.date.available2024-09-19T15:43:30Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the usefulness of a mean vascular density (MVD) and proliferative activity labeling index (LI) in gliomas and meningiomas as biological markers in histological grading. MATERIALS AND METHODS: Our study included 18 cases of glioma and 36 cases of meningioma. These cases were graded according to the WHO classification. CD-34 and Ki-67 immunohistochemical methods were used on paraffin-embedded tissues. Distribution of CD-34 and Ki-67 LI values were determined for different histologic grades of gliomas and meningiomas. The results were analyzed with statistical methods. RESULTS: In gliomas, the values of Ki-67 were detected as 3.33±2.50 in grade I, 5.01±2.28 in grade III and 10.33±4.85 in grade IV. The mean values of CD-34 were found as 11.80± 9.71 in grade III glioma and 8.40±5.45 in grade IV glioma. The values of Ki-67 were detected as 4.40±0.40 in atypical, 4.26±4.05 in psammomatous and 3.69±3.24 in meningothelial meningioma. CD-34 expression was 19.60±0.20 in angiomatous meningioma and 6.14±1.91 in malignant meningioma. CONCLUSION: Our results show that Ki-67 LI and angiogenesis can be useful in tumor grading of gliomas. However, the score of angiogenesis and Ki-67 LI adds little information to predict tumor grade in meningiomas, in contrast to gliomas.en_US
dc.identifier.endpage181en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-33846669834en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage176en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14361
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectGliomaen_US
dc.subjectMeningiomaen_US
dc.subjectProliferative activityen_US
dc.titleThe importance of proliferative activity and angiogenesis in meningioma and gliomaen_US
dc.typeArticleen_US

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