Structure, Function, Molecular Genetics, Disease Associations and Therapeutic Potential of Mannose Binding Lectin: Review

Basit Öğe Kaydı
dc.contributor.authorGunesacar, Ramazan
dc.contributor.authorTastemir, Deniz
dc.contributor.authorYildirim, Ayse
dc.contributor.authorEryilmaz, Naciye
dc.date.accessioned2024-09-18T20:29:44Z
dc.date.available2024-09-18T20:29:44Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMannose binding lectin (MBL) which is a collagen like serum protein and primarily synthesized by the liver is a significant component of natural immune response. MBL molecule provides phagocytosis of those microorganisms by macrophages or activates the lectin pathway of complement system via C3 convertase by binding on sugar groups on the surfaces of multifarious microorganisms. The MBL2 gene is located on chromosome 10 at position 10q11.2-q21 and consists of four exons and three introns. Three genetic variations named as allel B (codon 54, GGC > GAC, Gly > Asp), allel C (codon 57, GGA > GAA, Gly > Glu) and allel D (codon 52, GCT > TGT, Arg > Cys) and affecting the serum levels and trimerization of MBL protein were detected on the first exon of MBL2 gene. An association was shown between MBL2 gene codon variants or low MBL serum levels and bacterial, viral and fungal infections or autoimmunity development. An association was also detected between high MBL serum levels and renal graft rejection, diabetic nephropathy and inflammatory diseases. In this review, relationships between MBL and diseases and therapeutic potential of the molecule were summarized along with the molecular structure, function and genetics of MBL.en_US
dc.identifier.doi10.5336/medsci.2010-19722
dc.identifier.endpage1261en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-80054728456en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1250en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2010-19722
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11037
dc.identifier.volume31en_US
dc.identifier.wosWOS:000297434700027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMannose-binding lectinen_US
dc.subjectgenetic variationen_US
dc.titleStructure, Function, Molecular Genetics, Disease Associations and Therapeutic Potential of Mannose Binding Lectin: Reviewen_US
dc.typeReview Articleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
247.07 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu