Ameliorating effects of tempol on methotrexate-induced liver injury in rats

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dc.contributor.authorPinar, Neslihan
dc.contributor.authorKaplan, Mahir
dc.contributor.authorOzgur, Tumay
dc.contributor.authorOzcan, Oguzhan
dc.date.accessioned2024-09-18T20:32:49Z
dc.date.available2024-09-18T20:32:49Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMethotrexate (MTX) is used in the treatment of certain types of cancers and chronic inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects, the most common of which are hepatotoxicity and nephrotoxicity. In the present study, we demonstrate the protecting influence of tempol related to oxidative stress in MTX-induced liver toxicity in rats using histopathological and biochemical parameters. The rats were divided into four groups: control group (group 1), tempol group (group 2), MTX group (group 3) and MTX + tempol group (group 4). The control group (group 1) received physiological saline for 10 days; the tempol group (group 2) received 30 mg/kg i.p. for 10 days, the MTX group (group 3) received a single dose of 20 mg/kg intraperitoneal (i.p.) on the fourth day of the study, and the MTX + tempol group (group 4) received a single dose of 20 mg/kg i.p. on the fourth day, followed by tempol 30 mg/kg i.p. for 10 days. Malondialdehyde (MDA), myeloperoxidase (MPO), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were found to be significantly lower in the MTX + tempol group then in the MTX group; while superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were found to be higher in the MTX + tempol group than in the MTX group. Tempol ameliorates vacuolic degeneration, inflammation and necrosis in MTX-treated rats. Our study demonstrates that tempol treatment after MTX administration ameliorates oxidative damage in liver tissue in rats.en_US
dc.identifier.doi10.1016/j.biopha.2018.03.147
dc.identifier.endpage764en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid29604595en_US
dc.identifier.scopus2-s2.0-85044503052en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage758en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2018.03.147
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11149
dc.identifier.volume102en_US
dc.identifier.wosWOS:000432583800088en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexateen_US
dc.subjectLiver injuryen_US
dc.subjectTempolen_US
dc.titleAmeliorating effects of tempol on methotrexate-induced liver injury in ratsen_US
dc.typeArticleen_US

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