Exploring the anti-cancer properties of essential oils from some Lamiaceae species against human cancer cells with multivariate analysis

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dc.authoridTURKMEN, Musa/0000-0001-9914-9523
dc.contributor.authorGezici, Sevgi
dc.contributor.authorTurkmen, Musa
dc.contributor.authorKarahan, Faruk
dc.date.accessioned2024-09-18T20:29:28Z
dc.date.available2024-09-18T20:29:28Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe present study was aimed to determine phytochemical characterization, anticancer and antioxidant activities of essential oils obtained from 11 Lamiaceae species, including Clinopodium serpyllifolium subsp. barbatum (P.H.Davis) Braeurouchler, Lavandula angustifolia Miller, Mentha pound piperita L., Mentha pulegium L., Ocimum basilicum L., Rosmarinus officinalis L., Salvia aramiensis Rech.f., Salvia fruticosa Miller, Salvia officinalis L., Satureja thymbra L., and Thymbra spicata L. taxa from Tueurorkiye. The chemical composition of the essential oils (EOs) was identified using GC -MS, and antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,20- azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging methods. Furthermore, the anticancer potential of the EOs was evaluated using MTT method against human cell lines, including hepatocellular carcinoma (HepG2), gastric carcinoma (NCI -N87), breast adenocarcinoma (MCF-7), human prostate carcinoma (LNCaP clone FGC-Luc2) cancer cells, and non -cancerous human umbilical vein endothelial cells (HUVECs). The antioxidant activities of the extracts varied from 31.96 to 74.96%. Consistent with antioxidant activities, the anticancer activities of the EOs of S. officinalis, L. angustifolia, and R. officinalis were significantly higher than others. However, almost all EOs were found to inhibit cell viability and induce apoptosis of cancer cells, while the EOs at different concentrations exhibited the highest anticancer activity against NCI -N87, followed by HepG2, MCF-7, and LNCaP cancer cells, with the IC50 value ranging from 10.98 +/- 0.12 to 78.08 +/- 1.21 mg/mL, respectively. Variability in phytochemical components, free radical scavenging and anticancer activities of EOs was revealed by principal component analysis (PCA) and agglomerative hierarchical clustering (AHC). The major components of the EOs distilled from Lamiaceae species were found as eucalyptol, thujone, linalool, linalyl acetate, pulegone, carvone and carvacrol at different concentrations in the EOs. Overall, it can be clearly concluded that the EO samples distilled from some medicinal plants belonging to the Lamiaceae family contain valuable phytochemical compounds and accordingly exhibit remarkable biological activities. (c) 2024 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.sajb.2023.10.057
dc.identifier.endpage296en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85185170260en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2023.10.057
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10869
dc.identifier.volume166en_US
dc.identifier.wosWOS:001172409500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLamiaceaeen_US
dc.subjectPhytochemical compositionen_US
dc.subjectCanceren_US
dc.subjectAntioxidanten_US
dc.subjectNatural producten_US
dc.subjectPCAen_US
dc.titleExploring the anti-cancer properties of essential oils from some Lamiaceae species against human cancer cells with multivariate analysisen_US
dc.typeArticleen_US

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