Protective Effects of Tyrosol Against DSS-Induced Ulcerative Colitis in Rats

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dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorTekeli, Ibrahim Ozan
dc.contributor.authorUyar, Ahmet
dc.contributor.authorGokcek, Ishak
dc.contributor.authorIsler, Cafer Tayer
dc.date.accessioned2024-09-18T21:00:27Z
dc.date.available2024-09-18T21:00:27Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment group (tyrosol+DSS 20 mg/kg). In the study, the active substances were administered to all animals for a period of 21 days. At the end of the study, malondialdehyde (MDA) levels increased (p < 0.001); GSH level (p < 0.05) along with GSH.Px (p < 0.01) and CAT (p < 0.001) activities decreased in the DSS-induced colitis group. However, with the administration of tyrosol, MDA and GSH levels along with GSH.Px and CAT activities came to the same levels as the control group. In the colitis group, an increase occurred in IL-6, COX-2, and NF-kappa B parameters, which created a significant difference compared to the control group (p < 0.001). Similarly, TNF-alpha levels also significantly increased with the administration of DSS (p < 0.05) which created a significant difference compared to the control group, while there was no difference among the other groups. As for the Nrf-2 data, it decreased with the administration of DSS which created a significant difference compared to the control group (p < 0.05), while there was no difference in other groups. In the colitis-induced group, IL-6, COX-2, and NF-kappa B gene expression levels also similarly increased but returned to the normal levels with the administration of tyrosol. In the histopathological scoring, the negativity that increased with the administration of DSS returned to the normal levels with the administration of tyrosol+DSS. In conclusion, according to the data obtained, tyrosol fixed the destruction picture in the DSS-induced colitis model, giving rise to thought that it has a protective effect.en_US
dc.description.sponsorshipMustafa Kemal Üniversitesi [18.M.013] Funding Source: Medlineen_US
dc.identifier.doi10.1007/s10753-019-01028-8
dc.identifier.endpage1691en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5en_US
dc.identifier.pmid31115770en_US
dc.identifier.scopus2-s2.0-85066155739en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1680en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-019-01028-8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12697
dc.identifier.volume42en_US
dc.identifier.wosWOS:000483660100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttyrosolen_US
dc.subjectDSSen_US
dc.subjectcolitisen_US
dc.subjectinflammationen_US
dc.titleProtective Effects of Tyrosol Against DSS-Induced Ulcerative Colitis in Ratsen_US
dc.typeArticleen_US

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