The effect of circulating androgens on bone mineral density in postmenopausal women

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dc.authoridAnkarali, Handan/0000-0002-3613-0523
dc.contributor.authorTok, EC
dc.contributor.authorErtunc, D
dc.contributor.authorOz, U
dc.contributor.authorCamdeviren, H
dc.contributor.authorOzdemir, G
dc.contributor.authorDilek, S
dc.date.accessioned2024-09-18T20:16:51Z
dc.date.available2024-09-18T20:16:51Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Osteoporosis is a common problem in postmenopausal period. Recent studies have suggested that endogenous and exogenous androgens may influence the bone mineral density in women. There is limited data about the effect of circulating androgens on bone density in postmenopausal women. Aim: The aim of this study was to evaluate the effect of circulating androgens of ovarian and adrenal origin on bone mineral density in postmenopausal women. Materials and methods: This cross-sectional study included 178 postmenopausal women, who had never been treated with hormonal therapy or calciotropic agents. Serum free testosterone, dehydroepiandrosterone sulfate and androstenedione levels and their relationship with bone mass (dual X-ray absorptiometry) were evaluated. Results: Serum free testosterone and DHEAS levels were correlated positively with bone mineral density at lumbar spine and femoral neck (P < 0.001). However, stepwise linear regression analyses revealed a differential effect of androgens on bone density. Serum free testosterone was among the independent predictor of bone density at lumbar spine (trabecular bone), whereas serum DHEAS level was of bone density at femoral neck (cortical bone). Conclusion: This study suggests that endogenous androgens are influential on bone density in postmenopausal women. However, regression analyses revealed a differential effect of androgens on different bone types. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.maturitas.2003.11.007
dc.identifier.endpage242en_US
dc.identifier.issn0378-5122
dc.identifier.issn1873-4111
dc.identifier.issue3en_US
dc.identifier.pmid15207889en_US
dc.identifier.scopus2-s2.0-2942716746en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1016/j.maturitas.2003.11.007
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9782
dc.identifier.volume48en_US
dc.identifier.wosWOS:000222567800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofMaturitasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendogenous androgensen_US
dc.subjectbone mineral densityen_US
dc.subjectpostmenopausal womenen_US
dc.titleThe effect of circulating androgens on bone mineral density in postmenopausal womenen_US
dc.typeArticleen_US

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