Short term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormones

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dc.contributor.authorSagkan Ozturk, Aliye
dc.contributor.authorAydin, Mehmetq
dc.contributor.authorBozkurt, Yesim Akaydin
dc.contributor.authorKucukgul, Altug
dc.contributor.authorOzturk, Atakan
dc.date.accessioned2024-09-18T20:08:22Z
dc.date.available2024-09-18T20:08:22Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractGastric outlet obstruction (GOO) is caused mainly by pyloric or duodenal blockage; gastric surgery and vagotomy are effective treatments. We investigated the short term effects of experimental GOO and truncal vagotomy (TV) on gut hormone levels. We used 8-week-old male Wistar rats divided randomly into four groups: control, GOO, TV, and GOO + TV. At the end of the experiment, blood and tissue samples of the pylorus and fundus were obtained for biochemical and immunohistochemical analysis. Gastric motility decreased in the TV group, but there was no difference in food intake compared to the control group; water consumption and urine output were increased. Feces excretion and food intake decreased due to loss of food movement from the stomach of GOO and GOO + TV rats. Levels of insulin and ghrelin were lower than for the control group, but levels of cholecystokinin were higher. Leptin and glucagon-like peptide 1 levels were increased in the GOO group, while somatostatin was decreased. Leptin immunostaining levels were decreased in the GOO + TV group. Gastrin and neuropeptide Y levels were lower in the GOO and GOO + TV groups compared to the other groups. We found that both gut hormone levels related to gastric motility and metabolism, and immunohistochemical staining of the stomach tissue were altered by TV and GOO. Measuring changes in gut hormones following gastric surgery could be useful for monitoring the effectiveness of treatment.en_US
dc.description.sponsorshipScientific Research Projects Office of Hatay Mustafa Kemal University [10060]en_US
dc.description.sponsorshipOur study was supported by the Scientific Research Projects Office of Hatay Mustafa Kemal University [Project no. 10060].en_US
dc.identifier.doi10.1080/10520295.2021.1896780
dc.identifier.endpage98en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid33722110en_US
dc.identifier.scopus2-s2.0-85102726208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1896780
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8799
dc.identifier.volume97en_US
dc.identifier.wosWOS:000629439100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholecystokininen_US
dc.subjectgastric outleten_US
dc.subjectgastrinen_US
dc.subjectghrelinen_US
dc.subjectgut hormonesen_US
dc.subjectgut motilityen_US
dc.subjectleptinen_US
dc.subjectmotilinen_US
dc.subjectneuropeptide Yen_US
dc.subjectobstructionen_US
dc.subjectratsen_US
dc.subjectsomatostatinen_US
dc.subjectvagotomyen_US
dc.titleShort term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormonesen_US
dc.typeArticleen_US

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