Expression of inducible nitric oxide synthase in human cutaneous leishmaniasis
Yükleniyor...
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cutaneous leishmaniasis (CL) is an infectious disease caused by Leishmania parasite. The expression of inducible nitric oxide synthase (iNOS) and generation of nitric oxide in response to IFN-gamma and TNF-alpha is important in control of infection. The aim of the study was to determine the expression of iNOS in the lesions of Leishmania tropica, and whether there was a correlation between the level of expression and the duration of the disease. Punch biopsy was performed from patients (n = 29) and iNOS immunohistochemical staining was applied. Expression of iNOS protein was detected 82.8% of patients. There was a strong expression with the duration of the disease less than 6 months (p < 0.002). These findings demonstrate that iNOS has a role in L. tropica especially during the early stages of the infection.
Açıklama
Anahtar Kelimeler
cutaneous leishmaniasis, inducible nitric oxide synthase, Leishmania tropica, nitric oxide
Kaynak
Molecular and Cellular Biochemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
280
Sayı
1-2
