Subclinical Left Atrial and Ventricular Dysfunction in Acromegaly Patients: A Speckle Tracking Echocardiography Study

Basit Öğe Kaydı
dc.authoridGulumsek, Erdinc/0000-0003-0026-2396
dc.authoridKOCA, HASAN/0000-0002-6232-4567
dc.contributor.authorKoca, Hasan
dc.contributor.authorKoc, Mevlut
dc.contributor.authorSumbul, Hilmi Erdem
dc.contributor.authorIcen, Yahya Kemal
dc.contributor.authorGulumsek, Erdinc
dc.contributor.authorKoca, Fadime
dc.contributor.authorOzturk, Huseyin Ali
dc.date.accessioned2024-09-18T20:16:38Z
dc.date.available2024-09-18T20:16:38Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Although it is known that the left ventricular (LV) ejection fraction (EF) measured by echocardiography is preserved in patients with acromegaly, there is not enough information about the LV and left atrial strain (LV-GLS and LAS). Objective: This study aimed to evaluate the left ventricular (LV) and left atrial (LA) functions with strain echocardiography (SE) in patients with acromegaly. Methods: This study included 50 acromegaly patients with active disease and 50 healthy controls with similar age, gender, and body surface area. In addition to routine echocardiography examinations, LV-GLS and LAS measurements were performed with SE. Results: LAS and LV-GLS values were significantly lower in patients with acromegaly (p<0.05 for all). In bivariate analysis, systolic blood pressure, N-terminal prohormone of brain natriuretic peptide, Insulin-like growth factor-1, LA diastolic diameter, and LVMI levels were found to be positively correlated with both LAS and LV-GLS (p <0.05). IGF-1 level was strongly correlated with LAS and LV-GLS (p<0.001 and beta = 0.5 vs. p<0.001 and beta = 0.626, respectively); 48% of patients with acromegaly have reduced LV-GLS (<20%). Left ventricular mass-index (LVMI) independently determines the presence of reduced LV-GLS and each 1g/m(2) increase in LVMI level increases the likelihood of reduced LV-GLS by 6%. Conclusion: Although LV ejection fraction is normal in patients with acromegaly, LAS and LV-GLS values were significantly reduced. Apart from LVMI increase, another finding of cardiac involvement may be LAS and LV-GLS decrease. Therefore, in addition to routine echocardiography, LAS and LV-GLS may be useful to evaluate early signs of cardiac involvement before the occurrence of irreversible cardiac changes.en_US
dc.identifier.doi10.36660/abc.20201174
dc.identifier.endpage644en_US
dc.identifier.issn0066-782X
dc.identifier.issue3en_US
dc.identifier.pmid35137783en_US
dc.identifier.scopus2-s2.0-85127986350en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage634en_US
dc.identifier.urihttps://doi.org/10.36660/abc.20201174
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9650
dc.identifier.volume118en_US
dc.identifier.wosWOS:000791209200015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherArquivos Brasileiros Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros De Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEchocardiography/methodsen_US
dc.subjectAcromegalyen_US
dc.subjectCardiovascular Diseasesen_US
dc.subjectMyocardialen_US
dc.subjectDeformabilityen_US
dc.subjectDiagnosticen_US
dc.subjectImagingen_US
dc.subjectStroke Volumeen_US
dc.titleSubclinical Left Atrial and Ventricular Dysfunction in Acromegaly Patients: A Speckle Tracking Echocardiography Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu