Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer's disease

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dc.authoridBilgic, Yasemin/0000-0002-4909-7777
dc.authoridErcin, Nilufer/0000-0003-0137-4963
dc.authoridDemir, Enver/0000-0002-2620-6192
dc.contributor.authorBilgic, Yasemin
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorBilgic, Nilufer
dc.contributor.authorDogan, Hatice
dc.contributor.authorTutuk, Okan
dc.contributor.authorTurner, Cemil
dc.date.accessioned2024-09-18T19:54:15Z
dc.date.available2024-09-18T19:54:15Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPolyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer's disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt's forced swim, and Morris' water maze, to evaluate anxiety- and depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer's-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia-pretreated animals was remarkably worse as compared to their non-treated disease-induced counterparts. Hippocampal concentrations of amyloid-beta 42, amyloid precursor protein, and total tau protein were similarly increased in all disease-induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer's disease may exacerbate the disease. Although the results presented here emerge from an experimental/preclinical study, we suggest cautious and careful use of chia, especially in early-stage Alzheimer's patients, until future research in different experimental settings is conducted.en_US
dc.identifier.doi10.21307/ane-2018-031
dc.identifier.endpage331en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue4en_US
dc.identifier.pmid30624431en_US
dc.identifier.scopus2-s2.0-85059795732en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage322en_US
dc.identifier.urihttps://doi.org/10.21307/ane-2018-031
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7602
dc.identifier.volume78en_US
dc.identifier.wosWOS:000454991600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNencki Inst Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectchiaen_US
dc.subjectanxietyen_US
dc.subjectdepressionen_US
dc.subjectlearningen_US
dc.subjectmemoryen_US
dc.titleDetrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer's diseaseen_US
dc.typeArticleen_US

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