Effects of clinoptilolite on heavy metal levels in milk, proinflammatory cytokine responses (IL-1? and IL-6) and oxidative stress in dairy cows

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dc.authoridALUC, YASAR/0000-0002-2650-2290
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridDURU, OZKAN/0000-0002-8792-442X
dc.contributor.authorKurtdede, Efe
dc.contributor.authorKurtdede, Arif
dc.contributor.authorDuru, Sibel yasa
dc.contributor.authorDuru, Ozkan
dc.contributor.authorKara, Erdal
dc.contributor.authorAluc, Yasar
dc.contributor.authorKaya, Ufuk
dc.date.accessioned2024-09-18T20:11:30Z
dc.date.available2024-09-18T20:11:30Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe effects of clinoptilolite on milk copper (Cu), lead (Pb), zinc (Zn), cadmium (Cd) and iron (Fe) concentrations, proinflammatory cytokine responses, oxidative stress status, whole blood cell counts and liver and kidney functions were investigated in dairy cows exhibiting no signs of any kind of toxicity. Clinoptilolite was added to the feed at a dose of 200 mg kg(-1) body weight in the clinoptilolitetreated group (n = 14), but was not added to the feed in the control group (n = 7). In the milk samples (n = 21) collected before the experiment, the Cu, Pb, Zn, Cd and Fe values were 0.021 +/- 0.020, 0.104 +/- 0.01, 3.42 +/- 0.32, <0.000, 0.56 +/- 0.34 ppm, respectively. At the end of the experiment (30th day), among the elements measured in milk samples collected from the clinoptilolite-treated group, only the Pb value (0.076 +/- 0.01) was lower than the 0-day value of the clinoptilolite-treated group (0.104 +/- 0.01) and the 30th-day value of the control group (0.105 +/- 0.01) was found to be statistically lower. Changes determined at the end of clinoptilolite application in serum superoxide dismutase (SOD), malondialdehyde (MDA), albumin, glucose, urea and urine creatinine/urine total protein (uCr/uTP) values, which were interpreted as the effect of lead exposure before the trial, were evaluated as the positive effect of clinoptilolite. It was concluded that the addition of clinoptilolite to the feed in dairy cows caused a significant decrease in the amount of Pb in milk, and positive changes in the parameters related to oxidative stress in serum and in parameters related to renal function.en_US
dc.identifier.doi10.1556/004.2022.00035
dc.identifier.endpage320en_US
dc.identifier.issn0236-6290
dc.identifier.issn1588-2705
dc.identifier.issue4en_US
dc.identifier.pmid36350569en_US
dc.identifier.scopus2-s2.0-85144587531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.1556/004.2022.00035
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8909
dc.identifier.volume70en_US
dc.identifier.wosWOS:000904949300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Veterinaria Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectclinoptiloliteen_US
dc.subjectIL-1 betaen_US
dc.subjectIL-6en_US
dc.subjectmilken_US
dc.subjectMDAen_US
dc.subjectPben_US
dc.subjectSODen_US
dc.titleEffects of clinoptilolite on heavy metal levels in milk, proinflammatory cytokine responses (IL-1? and IL-6) and oxidative stress in dairy cowsen_US
dc.typeArticleen_US

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