Does the TMPRSS6 C > T Polymorphism Modify the Endurance Training Effects on Hematological Parameters?

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dc.authoridasikovali, semih/0000-0002-6589-3239
dc.authoridYigitturk, Oya/0000-0003-1930-498X
dc.contributor.authorKahraman, Cansu
dc.contributor.authorTurgay, Faruk
dc.contributor.authorYigitturk, Oya
dc.contributor.authorCanuzmez, Aykut Eren
dc.contributor.authorDurmaz, Burak
dc.contributor.authorAsikovali, Semih
dc.date.accessioned2024-09-18T20:16:54Z
dc.date.available2024-09-18T20:16:54Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study investigated the role of TMPRSS6 C > T polymorphism (TMPRP) on the effects of chronic aerobic training on main hematological parameters in male soccer referees, which is yet unknown. Two groups composed of total of 45 healthy male soccer referees and 42 sedentary were compared for hemogram, serum hepcidin, ferritin, and iron levels. TMPRP was determined from genomic DNA samples. Participants' physical and physiological (Yoyo endurance level-2 test) measurements were carried out. The athletic T carrier (Tc = TT + TC) group RBC count was significantly higher than the control (p < 0.01), whereas the athletic CC homozygous group serum iron and transferrin saturation (TS) were lower than the control depending on the TMPRP. The ferritin and iron values of the athletic Tc group were higher than of the athletic CC group (29.2% and 14.1%, respectively; p > 0.05) although the control Tc group RBC (p < 0.05) and iron (23.8%, p > 0.05) values were lower than the control CC due to genetic tendency. The training did not change hepcidin levels. These results suggest that the TMPRP can modify the endurance training effects on iron and TS levels and RBC count (in the CC and Tc groups) respectively. The CC group may be adversely affected for iron and TS from endurance trainings. It may be recommended that the training programs should be organized according to phenotype characteristics.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Uniten_US
dc.description.sponsorshipThis study was supported by the Ege University Scientific Research Projects Coordination Unit with the project number18-SPR-001.en_US
dc.identifier.doi10.1007/s12011-021-02876-y
dc.identifier.endpage2596en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue6en_US
dc.identifier.pmid34398419en_US
dc.identifier.scopus2-s2.0-85112513696en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2588en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02876-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9798
dc.identifier.volume200en_US
dc.identifier.wosWOS:000685407800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndurance trainingen_US
dc.subjectHepcidinen_US
dc.subjectIronen_US
dc.subjectPolymorphismen_US
dc.subjectTMPRSS6en_US
dc.titleDoes the TMPRSS6 C > T Polymorphism Modify the Endurance Training Effects on Hematological Parameters?en_US
dc.typeArticleen_US

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