Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease

Basit Öğe Kaydı
dc.authoridAydin Tufan, Muge/0000-0002-2686-9762
dc.authoridkucuksahin, orhan/0000-0003-4530-2304
dc.authoridKasapoglu, Esen/0000-0002-5866-7153
dc.authoridGonullu, Emel/0000-0002-6990-4206
dc.authoriderden, abdulsamet/0000-0002-8084-2018
dc.authoridCinar, Muhammet/0000-0002-6150-3539
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorBakirci, Sibel
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorGunal, Esen K.
dc.contributor.authorDogru, Atalay
dc.contributor.authorBayindir, Ozun
dc.contributor.authorDalkilic, Ediz
dc.date.accessioned2024-09-18T21:01:55Z
dc.date.available2024-09-18T21:01:55Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients with psoriasis or PsA have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes. Methods Data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis International Database were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression. Results A total of 444 patients (31.9%) had a family history of psoriasis and/or PsA. These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, and deformities, and less frequently achieved minimal disease activity. Among 444 patients, 335 only had psoriasis in their family, 74 had PsA, and 35 patients were not certain about having PsA and psoriasis in their family, so they were excluded from further analysis. In the multivariate analysis, family history of psoriasis was associated with younger age at onset of psoriasis (odds ratio [OR] 0.976) and presence of enthesitis (OR 1.931), whereas family history of PsA was associated with lower risk of plaque psoriasis (OR 0.417) and higher risk of deformities (OR 2.557). Family history of PsA versus psoriasis showed increased risk of deformities (OR 2.143) and lower risk of plaque psoriasis (OR 0.324). Conclusion Family history of psoriasis and PsA impacts skin phenotypes, musculoskeletal features, and disease severity. The link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets.en_US
dc.description.sponsorshipTurkish Society for Rheumatology; Scientific and Technological Research Council of Turkeyen_US
dc.description.sponsorshipSupported by the Turkish Society for Rheumatology. Dr. Bakirci's work was supported by the Scientific and Technological Research Council of Turkey and the Turkish Society for Rheumatology.en_US
dc.identifier.doi10.1002/acr.23836
dc.identifier.endpage68en_US
dc.identifier.issn2151-464X
dc.identifier.issn2151-4658
dc.identifier.issue1en_US
dc.identifier.pmid30680951en_US
dc.identifier.scopus2-s2.0-85070088336en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1002/acr.23836
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13080
dc.identifier.volume72en_US
dc.identifier.wosWOS:000505281300007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofArthritis Care & Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleImpact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Diseaseen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
285.66 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu