Phylogenetic Group/Subgroups Distributions, Virulence Factors, and Antimicrobial Susceptibility of Escherichia coli Strains from Urinary Tract Infections in Hatay

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dc.authoridYilmaz, Ebru Sebnem/0000-0001-6124-4832
dc.contributor.authorYilmaz, Ebru Sebnem
dc.contributor.authorAslantas, Ozkan
dc.date.accessioned2024-09-18T21:00:29Z
dc.date.available2024-09-18T21:00:29Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Nosocomial and community acquired urinary tract infections (UTIs) are one of the most encountered infections in the world. Methods: This study aimed to determine the antibiotic susceptibility, phylogeny, and virulence genes of 153 Escherichia coli strains isolated from UTIs. Antimicrobial susceptibility of the isolates to different classes of antimicrobials was determined by the VITEK-2 automated system. Presence of virulence genes and phylogenetic groups were investigated by PCR. Results: Regarding susceptibility to antimicrobials, ampicillin resistance was most abundant (67.3%), followed by amoxicillin-clavulanic acid (50.9%); least abundant was resistance to amikacin (1.3%) and nitrofurantoin (1.3%). Multi drug resistance (MDR) was observed in 34.6% of the isolates, and all isolates were found to be susceptible to imipenem, meropenem and fosfomycine. The majority of the isolates belonged to the phylogenetic group B2(3) (35.9%), followed by Al (20.9%), D1 (18.9%), D2 (12.4%), A0 (%5.9), B1 (3.9%) and B2 (1.9%). Among E. coli strains examined, 49% had iucD, 32.7% papE-F, 26.1% papC, 15% cnf2. 11.1% sfa, 7.8% cnf1, 1.3% afaE, 1.3% afaD, 1.3% hlyA, 0.7%f17a-A, 0.7% clpG and 0.7% eae A genes. Conclusions: Our research demonstrated that virulence factors were distributed among different phylogroup/subgroups, which play a role in UTIs pathogenesis in humans. For this reason, complex and detailed studies are required to determine the relationship between virulence factors and specific E. coil strains that cause UTIs in humans.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Fund [267]en_US
dc.description.sponsorshipThis study was granted by Hatay Mustafa Kemal University Scientific Research Fund (Project Number: 267).en_US
dc.identifier.doi10.1590/0037-8682-0429-2019
dc.identifier.issn0037-8682
dc.identifier.pmid32049204en_US
dc.identifier.scopus2-s2.0-85079337440en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/0037-8682-0429-2019
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12722
dc.identifier.volume53en_US
dc.identifier.wosWOS:000514147500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Medicina Tropicalen_US
dc.relation.ispartofRevista Da Sociedade Brasileira De Medicina Tropicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrinary Tract Infectionsen_US
dc.subjectVirulence genesen_US
dc.subjectPhylogenetic groupen_US
dc.subjectAntimicrobial resistanceen_US
dc.titlePhylogenetic Group/Subgroups Distributions, Virulence Factors, and Antimicrobial Susceptibility of Escherichia coli Strains from Urinary Tract Infections in Hatayen_US
dc.typeArticleen_US

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