Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats

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dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.authoridEtyemez, Muhammed/0000-0003-0497-1878
dc.authoridIsler, Cafer Tayer/0000-0002-1910-8316
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorCellat, Mustafa
dc.contributor.authorIsler, Cafer T.
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorKuzu, Muslum
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorAlakus, Halil
dc.contributor.authorGuvenc, Mehmet
dc.date.accessioned2024-09-18T19:54:31Z
dc.date.available2024-09-18T19:54:31Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractRheumatoid arthritis (RA) is a systemic chronic disease characterized by inflammation and synovitis. More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)-induced RA. The control group was given 1 ml of saline orally starting from the 8th day, and 0.2 ml of CFA was given to the RA, RA + Safranal and RA + Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1 ml of saline was given to the RA group, safranal was given at 200 mg/kg of body weight to the RA + MTX group, and 3 mg/kg of MTX to the RA + MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to be increased. Additionally, a deterioration in blood parameters, an increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, C-reactive protein, and malondialdehyde levels, and a decrease in reduced glutathione levels and glutathione peroxidase and catalase (CAT) activities were seen while tumor necrosis factor-alpha, interleukin-6 (IL-6), cyclooxygenase-2, nuclear factor kappa B levels were found to be increased. However, the safranal had a regulatory effect on all the values, except IL-6 and CAT, and blood parameters. Moreover, histopathological examination revealed that safranal reduced inflammatory cell infiltration and edema.en_US
dc.description.sponsorshipMustafa Kemal Universitesi [20.M.030]en_US
dc.description.sponsorshipMustafa Kemal Universitesi, Grant/Award Number: 20.M.030en_US
dc.identifier.doi10.1002/jbt.23140
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue9en_US
dc.identifier.pmid35674002en_US
dc.identifier.scopus2-s2.0-85131317811en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23140
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7783
dc.identifier.volume36en_US
dc.identifier.wosWOS:000807353800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatoryen_US
dc.subjectarthritis indexen_US
dc.subjectoxidative stressen_US
dc.subjectsaffronen_US
dc.subjectsynovitisen_US
dc.titleInvestigation of the effects of safranal on the experimentally created rheumatoid arthritis model in ratsen_US
dc.typeArticleen_US

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