Pathomorphological and Immunohistochemical Findings of Subacute Lobullary Calcifying Panniculitis in Two Cats

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dc.contributor.authorAlcigir, Mehmet Eray
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorAlcigir, Gunay
dc.date.accessioned2024-09-18T20:06:22Z
dc.date.available2024-09-18T20:06:22Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis report aimed to reveal the characteristics of calcifying panniculitis in two cats. Two biopsies taken from the lumbosacral region of an 8-month old and a 1-year old, male, mixed breed cats were evaluated. Macroscopically, there were masses of different sizes varying from 1.5 to 2.5 cm in diameter. The masses had a generally firmness and were grayish-white in colour. Histopathology revealed necrotic and degenerative lipocytes in lobules of subcutaenous fat tissue. In some areas, there were lymphocyte, macrophage and neutrophil leukocytes infiltrations and connective tissue proliferation. There were also large calcifying areas at the centre of degenerated-necrotic fat lobules. Alizarin Red S detected the calcifying areas and Masson's trichrome differentiated connective tissue proliferation. In ABC-P, CD3 slightly reacted with lymphocytes and lymphoblasts. Vimentin moderately reacted with connective tissue proliferation at the periphery of the necrotic areas and the septum. A1AC reacted in the cytoplasm of macrophages and peripheral necrotic areas. No reaction was determined with A1AT. In conclusion, such cases have not been documented in veterinary pathology. It is believed that the two cats possibly had a renal deficiency problem or nephrotic syndrome in the pathogenetic mechanism. It was also considered that A1AC (serine proteinase inhibitor) expressions could have a role in such cases despite there being no A1AT (another serine proteinase inhibitor) expression.en_US
dc.identifier.doi10.9775/kvfd.2017.18745
dc.identifier.endpage314en_US
dc.identifier.issn1300-6045
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85042149813en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2017.18745
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8486
dc.identifier.volume24en_US
dc.identifier.wosWOS:000429197100021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalcifying panniculitisen_US
dc.subjectCaten_US
dc.subjectImmunohistochemistryen_US
dc.subjectPathomorphologyen_US
dc.titlePathomorphological and Immunohistochemical Findings of Subacute Lobullary Calcifying Panniculitis in Two Catsen_US
dc.typeArticleen_US

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