Effect of electrical stimulation on oxidative stress in tissues in a rat model with incision wound

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dc.contributor.authorKazak, Filiz
dc.contributor.authorIsik, Egemen
dc.contributor.authorYurtal, Ziya
dc.contributor.authorAlakus, Ibrahim
dc.date.accessioned2024-09-18T20:16:47Z
dc.date.available2024-09-18T20:16:47Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractElectrical stimulation (ES) are known to have beneficial effects in wound healing. However, the effect of electrical stimulation in wound theraphy on the oxidant and antioxidant levels of various tissues in the body remains unclear. Here, we investigated the effects of electrical stimulation on the oxidative stress capacity of tissues in a rat model with a surgical incision wound on the lateral line of the femoral region. Rats divided in two groups: control and ES group. A longitudinal skin incision was made only from the right lateral line of all rats. ES was applied 200 mu s, 20 Hz, 2mA for 20 min during 15 days. Some oxidative stress parameters (malondialdehyde (MDA), reduced glutathione (rGSH), glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx) and catalase (CAT)) in tissues (brain, heart, kidney, liver, testis, gastrocnemius and quadriceps femoris muscle) were obtained spectrophotometrically. The ES reduced oxidative stress by decreasing MDA and simultaneously increasing different antioxidants in different tissues. The results suggest that incision wound could induce oxidative stress in tissues and electrical stimulation post-incision wound may have ameliorative effect.en_US
dc.identifier.doi10.56042/ijeb.v60i11.55921
dc.identifier.endpage831en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue11en_US
dc.identifier.startpage825en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v60i11.55921
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9745
dc.identifier.volume60en_US
dc.identifier.wosWOS:000928845300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectroteraphyen_US
dc.subjectGlucose-6-phosphate dehydrogenaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectM. gastrocnemiusen_US
dc.subjectM. quadriceps femorisen_US
dc.titleEffect of electrical stimulation on oxidative stress in tissues in a rat model with incision wounden_US
dc.typeArticleen_US

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