Investigation of the Bioactivity of Escin in Hydrogen Peroxide-Induced Oxidative Stress

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dc.contributor.authorKucukgul, A.
dc.contributor.authorIsgor, M. M.
dc.contributor.authorOnel, S. E.
dc.date.accessioned2024-09-18T20:19:51Z
dc.date.available2024-09-18T20:19:51Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEscin is a triterpene saponin obtained from the horse chestnut tree Aesculus hippocastanum L. (Hippo-castanaceae). The aim of this study is to investigate the bioactivity of escin against hydrogen peroxide-induced oxida-tive stress in quails. The study was performed in male Japanese quails (n=10) with similar pre-experimental weights (Coturnix japonica) on average. In order to create oxidative stress in quails, hydrogen peroxide was given to drinking water ad libitum for 1 week. At the end of the period, escin was injected intraperitoneally into the quails twice, every other day. The weights of the experimental animals were measured at the beginning and the end of the experiment and compared. In addition, the 10-day live weight change rate and feed intake rates of the experimental animals were also compared. Total antioxidant (TAC), total oxidant (TOC), and oxidative stress index (OSI) were measured colorimet-rically from serum and liver homogenates of animals in the experimental groups. In addition, IL-1 & beta; translation levels from serum samples were investigated by the ELISA method. According to the data obtained from the study, 10-day body weight change rates increased by 33% in the hydrogen peroxide added group compared to the control group, while an increase of 133% was observed in the escin-treated group. Besides, in serum and liver samples, it was found that escin showed strong antioxidant properties by decreasing the amount of TOC and increasing TAC levels in the group escin administered with hydrogen peroxide, compared to the group administered only with hydrogen peroxide. It was also observed that escin significantly suppressed the levels of IL-1 & beta; induced by hydrogen peroxide. As a result, escin was thought to be an alternative molecule in improving growth performance by showing significant antioxidant activity in the prevention of oxidative stress and inflammation in quails. However, multiple trials and detailed molec-ular analyzes are needed to obtain more detailed information on the subject.en_US
dc.identifier.doi10.12681/jhvms.30408
dc.identifier.endpage5838en_US
dc.identifier.issn1792-2720
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85165320066en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage5831en_US
dc.identifier.urihttps://doi.org/10.12681/jhvms.30408
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9908
dc.identifier.volume74en_US
dc.identifier.wosWOS:001027992500018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHellenic Veterinary Medical Socen_US
dc.relation.ispartofJournal of The Hellenic Veterinary Medical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEscinen_US
dc.subjectoxidative stressen_US
dc.subjectquailen_US
dc.subjectinflammationen_US
dc.subjectgrowthen_US
dc.titleInvestigation of the Bioactivity of Escin in Hydrogen Peroxide-Induced Oxidative Stressen_US
dc.typeArticleen_US

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