Effect of ghrelin on gastric myoelectric activity and gastric emptying in rats

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dc.contributor.authorTumer, Cemil
dc.contributor.authorOflazoglu, Hueda Diken
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorKelle, Mustafa
dc.contributor.authorTasdemir, Ezel
dc.date.accessioned2024-09-18T20:16:46Z
dc.date.available2024-09-18T20:16:46Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractGhrelin is a recently discovered peptide in the endocrine cells of the stomach, which may stimulate gastric motility via the vagal nerve pathway. However, the mechanism of ghrelin-induced changes in gastrointestinal motility has not been clearly defined. The purpose of this study was to investigate the pharmacological effects of ghrelin on gastric myoelectrical activity and gastric emptying in rats, and to investigate whether cholinergic activity is involved in the effects of ghrelin. The study was performed on Sprague-Dawley rats implanted with serosal electrodes for electrogastrographic recording. Gastric slow waves were recorded from fasting rats at baseline and after injection of saline, ghrelin, atropine, or atropin+ghrelin. Gastric emptying of non-caloric liquid was measured by the spectrophotometric method in conscious rats. Intravenous administration of rat ghrelin (20 mu g/kg) increased not only dominant frequency, dominant power and regularity of the gastric slow wave but also the gastric emptying rate when compared with the control rats (P < 0.01, P < 0.05, P < 0.05, P < 0.001 respectively). These stimulatory actions of ghrelin on both gastric myoelectrical activity and gastric emptying were not fully eliminated by pretreatment with atropine sulphate. These results taken together suggest that ghrelin may play a physiological role in the enteric neurotransmission controlling gastric contractions in rats. (c) 2007 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.regpep.2007.07.008
dc.identifier.endpage32en_US
dc.identifier.issn0167-0115
dc.identifier.issn1873-1686
dc.identifier.issue1-3en_US
dc.identifier.pmid17825442en_US
dc.identifier.scopus2-s2.0-38149107496en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2007.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9737
dc.identifier.volume146en_US
dc.identifier.wosWOS:000253278600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofRegulatory Peptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectelectrogastrographyen_US
dc.subjectgastric emptyingen_US
dc.subjectgastric myoelectrical activityen_US
dc.subjectghrelinen_US
dc.titleEffect of ghrelin on gastric myoelectric activity and gastric emptying in ratsen_US
dc.typeArticleen_US

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