The effect of circulating nitric oxide level on axial bone mineral density in postmenopausal Turkish women with rheumatoid arthritis: a preliminary report

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dc.authoridarinci Incel, Nurgul/0000-0002-0012-8720
dc.contributor.authorSahin, G
dc.contributor.authorGuler, H
dc.contributor.authorSezgin, M
dc.contributor.authorIncel, NA
dc.contributor.authorPolat, G
dc.date.accessioned2024-09-18T20:04:40Z
dc.date.available2024-09-18T20:04:40Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim is to investigate the differences in the circulating nitric oxide (NO) levels of rheumatoid arthritis (RA) patients, healthy controls and osteoporotic (OP) patients. We also examined whether the circulating NO levels may be correlated with bone mineral density (BMD) in RA patients. Forty-five patients with RA, 30 healthy women and 30 osteoporotic patients were recruited from the outpatient clinic. All the subjects were female and postmenopausal. Serum NO levels were measured (Nitrite/Nitrate, calorimetric method 1746081, Roche diagnostics, Mannheim, Germany) and BMD was measured at the spine and hip using dual energy X-Ray absorbtiometry (DEXA, Norland XR-46). Height and weight were measured and body mass index was calculated. Circulating NO levels were significantly higher in RA patients than other groups. Moreover, the RA group showed significantly higher BMD at lumbar spine and femoral neck regions compared to osteoporotic patients. However, the RA group showed significantly lower BMD at all sites than the controls. There was no correlation between circulating NO levels and BMD in all groups. We suggest that, unlike postmenopausal osteoporosis, inflammation induced osteoporosis is associated with RA is characterised by relatively preserved bone mass at the axial bone regions, and circulating NO levels as a parameter or determinant of inflammation are not correlated with axial BMD in RA patients.en_US
dc.identifier.doi10.1007/s00296-005-0091-2
dc.identifier.endpage809en_US
dc.identifier.issn0172-8172
dc.identifier.issue9en_US
dc.identifier.pmid16362366en_US
dc.identifier.startpage805en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-005-0091-2
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8299
dc.identifier.volume26en_US
dc.identifier.wosWOS:000238158300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbone mineral densityen_US
dc.subjectnitric oxideen_US
dc.subjectrheumatoid arthritisen_US
dc.titleThe effect of circulating nitric oxide level on axial bone mineral density in postmenopausal Turkish women with rheumatoid arthritis: a preliminary reporten_US
dc.typeArticleen_US

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