The Effects of Antivirals for Human Immunodeficiency Virus Treatment on Renal Functions

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dc.contributor.authorCabalak, Mehmet
dc.contributor.authorBal, Tayibe
dc.contributor.authorTurgut, Faruk Hilmi
dc.date.accessioned2024-09-18T20:26:51Z
dc.date.available2024-09-18T20:26:51Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractObjective: Turkey is among the countries with a low incidence of the human immunodeficiency virus (HIV) infections. When HIV cases are decreasing worldwide, our country is among the countries where the number of patients is rapidly increasing. Tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), and abacavir are the drugs used for HIV treatment in Turkey. The estimated glomerular filtration rate (eGFR) is widely used as a kidney function indicator. This study aimed to investigate the effects of TDF and TAF-based regimens on renal function. Materials and Methods: During the study period, 104 patients who are HIV-positive underwent treatment with an antiretroviral therapy (ART) regimen, of whom 60 fulfilled the inclusion criteria and were included in the study. This study retrospectively examined the effects of TAF and TDF-based regimens on eGFR and other routine parameters. Results: Patients receiving TDF-based regimens revealed significantly increased serum creatinine and decreased eGFR levels compared to pretreatment levels. Conversely, patients receiving a TAF-based regimen did not show significant changes in eGFR or serum creatinine levels. Conclusion: Our data indicate that eGFR levels decrease with a TDF-based regimen. Thus, with TDF as a component of the ART regimen, eGFR levels should be carefully monitored. TDF-free regimens should be used in patients who are predicted to have impaired renal function and those with renal function changes during treatment.en_US
dc.identifier.doi10.4274/mjima.galenos.2022.2021.22
dc.identifier.issn2147-673X
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2022.2021.22
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10568
dc.identifier.volume11en_US
dc.identifier.wosWOS:000800017500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHuman immunodeficiency virusen_US
dc.subjecttenofovir disoproxil fumarateen_US
dc.subjecttenofovir alafenamide fumarateen_US
dc.subjectrenal functionen_US
dc.subjectglomerular filtration rateen_US
dc.titleThe Effects of Antivirals for Human Immunodeficiency Virus Treatment on Renal Functionsen_US
dc.typeArticleen_US

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