Protective Effect of Thymoquinone in Experimental Testicular Torsion

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dc.authoridGonenci, Ramazan/0000-0002-4043-2612
dc.authoridYonden, Zafer/0000-0003-0708-5417
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorGokce, Ahmet
dc.contributor.authorOktar, Suleyman
dc.contributor.authorKoc, Ahmet
dc.contributor.authorGonenci, Ramazan
dc.contributor.authorYalcinkaya, Fatih
dc.contributor.authorYonden, Zafer
dc.contributor.authorDuru, Mehmet
dc.date.accessioned2024-09-18T20:59:20Z
dc.date.available2024-09-18T20:59:20Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. Materials and Methods: Experiments were performed on male C57BL/6 mice (8 weeks old, 20-25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), torsion/detorsion (TD) and TD+TQ. Mice, except the sham-operated group, were subjected to left unilateral torsion (720 degrees rotation in the clockwise direction). The experiments were finished after sham operation time for controls, 120 min torsion and 240 min detorsion for the other groups. In the TD+TQ group 10 mg TQ was injected intraperitoneally 30 min before detorsion. Results: In the TD group total oxidative stress (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were higher than in the controls. TQ treatment decreased MDA, TOS and OSI values, but did not affect the total antioxidant capacity and myeloperoxidase activity in the TD+TQ group. Upon histological examination, mice in the TD group displayed moderate-to-severe disruption of the seminiferous epithelium. Treatment with TQ resulted in significantly reduced histological damage associated with I/R injury. Conclusion: Our results suggested that TQ treatment may have a protective effect on testicular I/R injury. Copyright (C) 2010 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000318890
dc.identifier.endpage465en_US
dc.identifier.issn0042-1138
dc.identifier.issue4en_US
dc.identifier.pmid20628240en_US
dc.identifier.scopus2-s2.0-78650970044en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.1159/000318890
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12525
dc.identifier.volume85en_US
dc.identifier.wosWOS:000285582100015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular torsionen_US
dc.subjectThymoquinoneen_US
dc.subjectOxidative stressen_US
dc.subjectTestisen_US
dc.titleProtective Effect of Thymoquinone in Experimental Testicular Torsionen_US
dc.typeArticleen_US

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