THYMBRA SPICATA L. MODULATES CHROMIUM (III) CHLORIDE-INDUCED GENETIC AND OXIDATIVE DAMAGE IN VITRO

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dc.authoridDirican, Ebubekir/0000-0001-9260-5223
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorTurkez, Hasan
dc.date.accessioned2024-09-18T20:59:25Z
dc.date.available2024-09-18T20:59:25Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractChromium is a toxic heavy metal used in various industries and leads to environmental pollution due to improper handling. Cr exhibits oxidative stress mediated genotoxic damage although the mechanism of cellular damage caused by Cr has not been fully elucidated. On the other hand, Thymbra spicata L., a member of the Lamiaceae family, was recently investigated popularly of biological roles; mainly antioxidant and antimicrobial activities. However, there is very scarce data on the cytogenetic effects of Thyme species. Therefore, in this study, we aimed to determine whether T. spicata extracts conferred a protection against Chromium (III) chloride (CrCl3)-induced genotoxic and oxidative damage in vitro. For this aim, we determined sister chromatid exchange (SCE) rates and main antioxidant enzyme activities including catalase (CAT) superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in CrC3l (25 mu M) and T. spicata extracts (TSE) (25, 50, 100 mu M) treated human whole blood cultures (n=3) for 72h. T. spicata extracts at tested concentrations did not exhibit any negative effects on above studied parameters in culture tubes. Besides, the results of the present study indicated that the increases of SCE frequencies and the decreases of antioxidant enzyme activities by CrCl3 were minimized by the application of the T. spicata extracts. Our results firstly suggest that T. spicata augments the antioxidants defense against CrCl3 induced toxicity. Based on the results of this study, it may be concluded that dose controlled T. spicata diet may play a protective role in the process of Cr mutagenesis and/or carcinogenesis.en_US
dc.identifier.endpage1485en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue6en_US
dc.identifier.startpage1480en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12564
dc.identifier.volume21en_US
dc.identifier.wosWOS:000305776800019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymbra spicataen_US
dc.subjectChromium (III) chlorideen_US
dc.subjecthuman erythrocytesen_US
dc.subjecthuman lymphocytesen_US
dc.subjectin vitroen_US
dc.subjectoxidative stressen_US
dc.titleTHYMBRA SPICATA L. MODULATES CHROMIUM (III) CHLORIDE-INDUCED GENETIC AND OXIDATIVE DAMAGE IN VITROen_US
dc.typeArticleen_US

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