Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats

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dc.authoridCOMEZ, MEHMET/0000-0003-0821-5148
dc.authoridAYDIN, TUBA/0000-0002-7653-6480
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorComez, Mehmet Selim
dc.contributor.authorCellat, Mustafa
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorBorazan, Yakup
dc.contributor.authorAydin, Tuba
dc.contributor.authorGokcek, Ishak
dc.contributor.authorTurk, Erdinc
dc.date.accessioned2024-09-18T20:28:15Z
dc.date.available2024-09-18T20:28:15Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe antioxidant and cardioprotective effects of oleuropein have been reported in several studies; however, its effect on ketamine cardiotoxicity has not been known yet. The aim of this study was to investigate the effects of oleuropein in ketamine-induced cardiotoxicity model in rats. A total of 28 male Wistar Albino rats were included in the study and they were randomly divided into four groups, each having seven rats. Group 1 (control): rats were given 1 mL of DMSO by oral gavage method for 7 days. Group 2 (ketamine): on the seventh day of the study, 60 mg/kg ketamine was administered intraperitoneally. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Group 3 (oleuropein): rats were given 200 mg/kg/day oleuropein by oral gavage method for 7 days. Group 4 (oleuropein + ketamine): rats were given 1 x 200 mg/kg oleuropein by oral gavage method for 7 days. Furthermore, 60 mg/kg ketamine was administered intraperitoneally on the seventh day of the experiment. Then, 60 mg/kg ketamine was administered intraperitoneally every 10 min for 3 h. Serum cardiac marker (TnI, CK-MB and CK) levels were measured. Histopathological analysis was performed on a portion of the cardiac tissue. Cardiac tissue oxidative stress and antioxidant markers (MDA, GSH, GSH.Px and CAT), TNF-alpha, IL-6, NF-kappa B, COX-2 and Nrf-2 gene expressions, and protein conversion levels of related genes were determined. Data obtained showed that ketamine administration increased MDA (p < 0.001), TNF-alpha (p < 0.01), IL-6 (p < 0.01), COX-2 (p < 0.001) and NF-kappa B (p < 0.001) levels, as well as serum TnI (p < 0.001), CK-MB (p < 0.001) and CK (p < 0.01) levels whereas decreased GSH (p < 0.05) and Nrf-2 (p < 0.05) levels, as well as GSH-Px (p < 0.001) and CAT (p < 0.05) enzyme activities. Oleuropein administration was observed to decrease MDA, TNF-alpha, IL-6, COX-2, NF-kappa B, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group. This study showed that oleuropein administration reversed the increased oxidative stress and inflammation as a result of the use of ketamine and had protective effects on the heart.en_US
dc.description.sponsorshipScientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey [18.M.062/2018]en_US
dc.description.sponsorshipThis study funded by the Scientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey (No: 18.M.062/2018).en_US
dc.identifier.doi10.1007/s00210-020-01870-w
dc.identifier.endpage1699en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue9en_US
dc.identifier.pmid32383030en_US
dc.identifier.scopus2-s2.0-85084315429en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1691en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-020-01870-w
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10811
dc.identifier.volume393en_US
dc.identifier.wosWOS:000531398000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKetamineen_US
dc.subjectOleuropeinen_US
dc.subjectCardiotoxicityen_US
dc.titleProtective effect of oleuropein on ketamine-induced cardiotoxicity in ratsen_US
dc.typeArticleen_US

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