Investigation of ACE Genome Insertion/Deletion Correlation with Immunohistochemical Profile in Pituitary Adenomas

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dc.authoridElmaci, Ilhan/0000-0001-9433-0307
dc.authoridISIK, NEJAT/0000-0002-6809-4969
dc.authoridBayrak, Omer Faruk/0000-0001-7562-6604
dc.contributor.authorAltas, Murat
dc.contributor.authorBayrak, Omer Faruk
dc.contributor.authorSerefhan, Alpay
dc.contributor.authorSilav, Gokalp
dc.contributor.authorCoskun, Kerim Kenan
dc.contributor.authorCerci, Ajlan
dc.contributor.authorIsik, Nejat
dc.date.accessioned2024-09-18T19:54:22Z
dc.date.available2024-09-18T19:54:22Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAIM: The deletion polymorphism of the angiotensin-converting enzyme (ACE) genome causes neoplastic development in several organs by increasing the angiotensin 2 (A2) formation. In this study, we aimed to identify the ACE genome insertion/deletion polymorphism in pituitary adenomas and to compare it with the control group. MATERIAL and METHODS: Patients operated for pituitary adenomas were included in the study. Genomic DNA was extracted from tumoral tissues and peripheral blood samples of the patients by using the Miller method. Primary sequence was selected via targeting the polymorphic region of intron 16 of ACE genome 17q23. DNA samples were multiplied by PCR using HACE3s and HACE3as primers. RESULTS: Twenty-one operated cases were studied. In the study group; 44% of the patients were identified as DID, 33% of them as I/D and 23% of them as I/I. In 60%, D allele was identified. According to immunohistochemical investigation, we found that 100% of the patients with Cushing adenoma were D/D alleles. CONCLUSION: Presence of high rate of ACE genome deletion in patients with pituitary adenoma and grade 3-4 patients suggest that ACE genome polymorphism can be a risk factor for the development of pituitary adenomas.en_US
dc.identifier.doi10.5137/1019-5149.JTN.7423-12.0
dc.identifier.endpage469en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid24101265en_US
dc.identifier.scopus2-s2.0-84881501913en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage464en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.7423-12.0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7692
dc.identifier.volume23en_US
dc.identifier.wosWOS:000322926200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiotensin-converting enzymeen_US
dc.subjectPituitary adenomasen_US
dc.subjectGeneen_US
dc.titleInvestigation of ACE Genome Insertion/Deletion Correlation with Immunohistochemical Profile in Pituitary Adenomasen_US
dc.typeArticleen_US

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