Investigation of the Relation Between FAS, FASLG Polymorphisms and Serum Fas, FasL Levels in Patients with Psoriasis

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dc.contributor.authorDuran, Gulay Gulbol
dc.contributor.authorKasap, Mulkiye
dc.contributor.authorGunesacar, Ramazan
dc.contributor.authorDogramaci, Asena Cigdem
dc.contributor.authorDenli, Yasar Gul
dc.date.accessioned2024-09-18T20:20:01Z
dc.date.available2024-09-18T20:20:01Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Psoriasis is a multifactorial and inflammatory chronic skin disease indicated with T-cell-mediated keratinocyte hyper-proliferation. Demographic, epidemiological (family, twin), serological, and genetic studies have clearly demonstrated that psoriasis is a polygenic and multifactorial disease. Aim: The objectives of the study are; to determine the prevalence of the polymorphisms of FAS (Fas cell surface receptor gene) -671 A>G (rs: 1800682) and FASLG (Fas ligand gene) -844 T>C (rs: 763110), to investigate the serum levels of sFas and sFasL, and also to discover any relationship between gene polymorphisms and serum levels in psoriatic patients. Material and Methods: 50 treated and 69 untreated patients, and 140 healthy controls were included in the study. Polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The serum levels were measured in randomly selected treated (39) and untreated (40) patients, also in 84 healthy controls using micro-ELISA technique. Results: There was no statistical difference between polymorphisms in the patient and control groups. However, sFas and sFasL levels in both treated and untreated patients were higher than that of the controls. Conclusion: The investigated FAS and FASLG polymorphisms were not found to be directly associated with the psoriasis. Elevated sFas and sFasL levels in psoriatic patients showed that these factors may possess a significant role in the pathogenesis of psoriasis.en_US
dc.description.sponsorshipCukurova University Scientific Research Projects Unit, Adana, Turkey [TF2010D13]en_US
dc.description.sponsorshipThis research was financed by Cukurova University Scientific Research Projects Unit (Project Number: TF2010D13), Adana, Turkey. This study has been in accordance with both legal and ethical grounds.en_US
dc.identifier.doi10.2478/rrlm-2018-0024
dc.identifier.endpage333en_US
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85050533520en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.2478/rrlm-2018-0024
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10014
dc.identifier.volume26en_US
dc.identifier.wosWOS:000440456200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Pressen_US
dc.relation.ispartofRevista Romana De Medicina De Laboratoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFASen_US
dc.subjectFASLGen_US
dc.subjectPsoriasisen_US
dc.subjectPCR-RFLPen_US
dc.titleInvestigation of the Relation Between FAS, FASLG Polymorphisms and Serum Fas, FasL Levels in Patients with Psoriasisen_US
dc.typeArticleen_US

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