Characterization of immunohistochemical markers in triple negative breast carcinomas

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dc.contributor.authorAtik, E.
dc.contributor.authorGuray, M.
dc.contributor.authorOzgur, T.
dc.contributor.authorCanda, T.
dc.date.accessioned2024-09-18T20:06:12Z
dc.date.available2024-09-18T20:06:12Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: Triple negative (TN) breast carcinomas (estrogen receptor/ER, progesterone receptor/PR and HER-2/neu negative) constitute 15-25% of all breast carcinomas and have been correlated with aggressive behavior and poor prognosis. Our aim was to describe and characterize the immunophenotype of these tumors in a group of patients from Turkey. Methods: We used the immunohistochemical markers CK5/6, CK14, EGFR, E-cadherin, p53 and androgen receptor. Formalin-fixed, paraffin-embedded tissues from 51 breast carcinoma patients (36 TN and 15 non TN) were included into this study. Results: The mean values of the distribution of immunohistochemical markers in TN vs non-TN groups were as follows: CK5/6 78.4 vs 5.3%, CK14 84.8 vs 8%, EGFR 87.2 vs 8%, E-cadherin 96.9 vs 53.2%, p53 87.3 vs 7.3% and androgen receptor 89.5 vs 33.3% (all p-values<0.001). CK5/6 stained significantly different in the grade 2 and 3 cases (p=0.035) in the TN group. The other markers demonstrated no significant differences between grades. Conclusion: TN breast carcinomas in Turkish patients express basal cytokeratins, and have high levels of p53 compared to non-TN breast carcinomas.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Committee [02M0102]en_US
dc.description.sponsorshipWe would like to thank Dr. Nazan Savas from the Department of Public Health for her help in statistical analysis. This study was financially supported by Mustafa Kemal University Scientific Research Committee (Grant No: 02M0102).en_US
dc.identifier.endpage890en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4en_US
dc.identifier.pmid24344013en_US
dc.identifier.scopus2-s2.0-84893133068en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage886en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8373
dc.identifier.volume18en_US
dc.identifier.wosWOS:000331593700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast carcinomaen_US
dc.subjectimmunophenotypeen_US
dc.subjecttriple negativeen_US
dc.titleCharacterization of immunohistochemical markers in triple negative breast carcinomasen_US
dc.typeArticleen_US

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