Protective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brain

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dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorAras, Mustafa
dc.contributor.authorUrfali, Boran
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorOzgur, Tumay
dc.contributor.authorUlutas, Kemal Turker
dc.contributor.authorUrfali, Senem
dc.contributor.authorAltas, Murat
dc.date.accessioned2024-09-18T20:08:10Z
dc.date.available2024-09-18T20:08:10Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to assess the effects of minocycline on cerebral ischemia-reperfusion (I/R) injury in rats. The study was carried out on 24 male Wistar albino rats, weighing 200-250 g, which were divided into three groups: (i) control (n = 8), (ii) I/R (n = 8) and (iii) I/R + minocycline (n = 8). Minocycline was administrated at a dose of 90 mg/kg p.o. to the I/R group 48, 24 and 1 h before ischemia. Following bilateral exposure of the common carotid arteries by anterior cervical dissection and separation of the vagus nerve, I/R injury was performed by occlusion. Following reperfusion, malondialdehyde (MDA), superoxide dismutase, glutathione peroxidase and catalase levels in the blood and brain tissue, and creatine kinase (CK), CK-BB, lactate dehydrogenase (LDH), neuron-specific enolase (NSE) and protein S100 beta levels in the blood were measured and the histopathological changes were monitored. Regarding histopathological evaluation, symptoms of degeneration were significantly improved in the I/R + minocycline group compared to the I/R-only group. Statistical analysis of the biochemical parameters revealed significant differences in MDA (p < 0.001), nitric oxide (p < 0.05), CK (p < 0.05) and CK-MB (p < 0.05) levels between the I/R + minocycline group and the I/R group. According to the literature, the effect of minocycline is firstly assessed by LDH, CK-MB, NSE and S-100 beta analysis in addition to antioxidant status and histopathological analysis. (C) 2014 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000362202
dc.identifier.endpage178en_US
dc.identifier.issn1016-2291
dc.identifier.issn1423-0305
dc.identifier.issue3en_US
dc.identifier.pmid24801142en_US
dc.identifier.scopus2-s2.0-84904063629en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage172en_US
dc.identifier.urihttps://doi.org/10.1159/000362202
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8682
dc.identifier.volume49en_US
dc.identifier.wosWOS:000339398900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPediatric Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCerebral ischemia-reperfusion injuryen_US
dc.subjectMinocyclineen_US
dc.subjectMalondialdehydeen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectProtein S100 betaen_US
dc.titleProtective Effects of Minocycline against Short-Term Ischemia-Reperfusion Injury in Rat Brainen_US
dc.typeArticleen_US

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