Histopathologic and metabolic effect of ursodeoxycholic acid treatment on PCOS rat model

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.contributor.authorGozukara, Ilay
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorOzgur, Tumay
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorPinar, Neslihan
dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorKucur, Suna Kabil
dc.date.accessioned2024-09-18T20:26:45Z
dc.date.available2024-09-18T20:26:45Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) treatment on a polycystic ovary syndrome (PCOS) rat model. Thirty-two female Wistar-Albino rats were randomly divided into four groups as follows - group 1: sham group (n: 8), group 2: letrozole-induced PCOS group (n: 8), group 3: letrozole-induced PCOS plus metformin-treated (500 mg/kg) group (n: 8) and group 4: letrozole-induced PCOS plus UDCA (150 mg/kg)-treated group (n: 8). Histopathologic examination of the ovaries, circulating estrone (E1), estradiol (E2), testosterone, androstenedione, glucose, insulin and lipid profiles were evaluated. Histopathologic examination results revealed that groups 3 and 4 had significantly lower cystic and atretic follicles compared to group 2. Besides, group 4 had significantly higher antral follicles than group 2 (8.5 +/- 2.9 versus 5.4 +/- 1.1; p: 0.001). Furthermore, total testosterone (4.9 +/- 2.8 versus 8.8 +/- 2.9; p=0.004) and insulin levels were significantly lower in group 4 compared to group 2 (1.7 +/- 0.08 versus 2.1 +/- 0.5; p = 0.02). However, lipid parameters, E1, E2, glucose and HOMA-IR were comparable between the groups. Our study results demonstrated that UDCA therapy improves ovarian morphology and decreases total testosterone and insulin levels.en_US
dc.description.sponsorshipDepartment of Scientific Research Project's in Mustafa Kemal University [13240]en_US
dc.description.sponsorshipThis study was financially supported by Department of Scientific Research Project's (Project No 13240) in Mustafa Kemal University.en_US
dc.identifier.doi10.3109/09513590.2015.1134478
dc.identifier.endpage497en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue6en_US
dc.identifier.pmid26772475en_US
dc.identifier.scopus2-s2.0-84954443662en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage492en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2015.1134478
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10519
dc.identifier.volume32en_US
dc.identifier.wosWOS:000376519000016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistopathologyen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjecttreatmenten_US
dc.subjectursodeoxycholic aciden_US
dc.titleHistopathologic and metabolic effect of ursodeoxycholic acid treatment on PCOS rat modelen_US
dc.typeArticleen_US

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