Diffuse osteosclerosis in a patient with prostate cancer

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dc.authoridUstun, Ihsan/0000-0002-5848-1586
dc.authoridSumbul, Ahmet Taner/0000-0002-5573-906X
dc.contributor.authorUstun, N.
dc.contributor.authorUstun, I.
dc.contributor.authorOzgur, T.
dc.contributor.authorAtci, N.
dc.contributor.authorAydogan, F.
dc.contributor.authorSumbul, A. T.
dc.contributor.authorTurhanoglu, A. D.
dc.date.accessioned2024-09-18T20:04:40Z
dc.date.available2024-09-18T20:04:40Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was -2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.en_US
dc.identifier.doi10.1007/s00198-013-2545-9
dc.identifier.endpage1185en_US
dc.identifier.issn0937-941X
dc.identifier.issn1433-2965
dc.identifier.issue3en_US
dc.identifier.pmid24136106en_US
dc.identifier.scopus2-s2.0-84894543631en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1181en_US
dc.identifier.urihttps://doi.org/10.1007/s00198-013-2545-9
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8300
dc.identifier.volume25en_US
dc.identifier.wosWOS:000331559200041en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofOsteoporosis Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone mineral densityen_US
dc.subjectOsteoblastic bone metastasisen_US
dc.subjectProstate canceren_US
dc.titleDiffuse osteosclerosis in a patient with prostate canceren_US
dc.typeArticleen_US

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