DNA Methylation of BDNF Gene in Schizophrenia

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.contributor.authorCopoglu, Umit Sertan
dc.contributor.authorIgci, Mehri
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorKokacya, M. Hanifi
dc.contributor.authorIgci, Yusuf Ziya
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorAri, Mustafa
dc.date.accessioned2024-09-18T20:06:11Z
dc.date.available2024-09-18T20:06:11Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Although genetic factors are risk factors for schizophrenia, some environmental factors are thought to be required for the manifestation of disease. Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity. It has been suggested that BDNF may play a role in the pathophysiology of schizophrenia. It is established that methylation status of the BDNF gene is associated with fear learning, memory, and stressful social interactions. In this study, we aimed to investigate the DNA methylation status of BDNF gene in patients with schizophrenia. Material/Methods: The study included 49 patients (33 male and 16 female) with schizophrenia and 65 unrelated healthy controls (46 male and 19 female). Determination of methylation pattern of CpG islands was based on the principle that bisulfite treatment of DNA results in conversion of unmethylated cytosine residues into uracil, whereas methylated cytosine residues remain unmodified. Methylation-specific PCR was performed with primers specific for either methylated or unmethylated DNA. Results: There was no significant difference in methylated or un-methylated status for BDNF promoters between schizophrenia patients and controls. The mean duration of illness was significantly lower in the hemi-methylated group compared to the non-methylated group for BDNF gene CpG island-1 in schizophrenia patients. Conclusions: Although there were no differences in BDNF gene methylation status between schizophrenia patients and healthy controls, there was an association between duration of illness and DNA methylation.en_US
dc.identifier.endpage402en_US
dc.identifier.issn1643-3750
dc.identifier.pmid26851233en_US
dc.identifier.scopus2-s2.0-84957553964en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8351
dc.identifier.volume22en_US
dc.identifier.wosWOS:000369909900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectDNA Methylationen_US
dc.subjectEpigenesis, Geneticen_US
dc.subjectSchizophrenia and Disorders with Psychotic Featuresen_US
dc.titleDNA Methylation of BDNF Gene in Schizophreniaen_US
dc.typeArticleen_US

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