Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia

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dc.authoridYanik, Medaim/0000-0001-5936-0017
dc.contributor.authorAkyol, O
dc.contributor.authorYanik, M
dc.contributor.authorElyas, H
dc.contributor.authorNamli, M
dc.contributor.authorCanatan, H
dc.contributor.authorAkin, H
dc.contributor.authorYuce, H
dc.date.accessioned2024-09-18T20:25:19Z
dc.date.available2024-09-18T20:25:19Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractReactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Polymorphisms in the genes encoding antioxidant enzymes should therefore result in predisposition to schizophrenia. The present study was performed to assess; whether there is a genetic association between a functional polymorphism (Ala-9Val) in the human Mn-SOD gene in schizophrenic patients (n=153) and healthy controls (n=196) using a PCR/RFLP method. Significant differences in the genotypic distribution between schizophrenics and controls were observed. Genotypic distribution with 14 (9.2%) Ala/Ala, 106 (69.3%) Ala/Val and 33 (21.6%) Val/Val subjects, in schizophrenia was different from those of controls with 46 (23.5%), 83 (42.3%) and 67 (34.21/6), respectively (p<0.0001). When the patents with schizophrenia were divided into the subgroups as disorganized, paranoid and residual. there was a significant difference In genotypic distribution among the subgroups (chi(2)=11.35, df=4 p=0.023). This association between -9Ala Mn-SOD allele and schizophirenia suggests that -9Ala variant may have a contribution in the physiopathogenesis of schizophrenia. Further investigations are warranted in larger populations with other susceptible genes that might be associated with schizophrenia. (C) 2004 Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.pnpbp.2004.10.014
dc.identifier.endpage131en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue1en_US
dc.identifier.pmid15610954en_US
dc.identifier.scopus2-s2.0-19944402500en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2004.10.014
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10233
dc.identifier.volume29en_US
dc.identifier.wosWOS:000226317600017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgene polymorphismen_US
dc.subjectmanganese superoxide dismutaseen_US
dc.subjectschizophreniaen_US
dc.titleAssociation between Ala-9Val polymorphism of Mn-SOD gene and schizophreniaen_US
dc.typeReview Articleen_US

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