Effects of human granulocyte-colony stimulating factor on fracture healing in rats

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dc.contributor.authorBozlar, M
dc.contributor.authorAslan, B
dc.contributor.authorKalaci, A
dc.contributor.authorBaktiroglu, L
dc.contributor.authorYanat, AN
dc.contributor.authorTasci, A
dc.date.accessioned2024-09-18T21:07:41Z
dc.date.available2024-09-18T21:07:41Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Granulocyte colony stimulation factor (G-CSF) is generally used to prevent and cure the neutropenia associated with chemotherapy and bone marrow transplantation. In addition to its effects on neutrophil function, G-CSF was found to have the characteristic of modulating the cytokines in the inflammatory response. Then, the question to answer is whether it has any effect on fracture healing and to what extent? In this study, we test the effects of G-CSF on the healing of tibia fracture in a rat model. Methods: This study was performed at Harran University, Sanliurfa, Turkey between July 2003 and August 2004. Twenty female, healthy Sprague-Dawley rats, weighing between 250 and 300 gm were divided into 2 groups, and their tibiae broken. The rats in the G-CSF group were injected subcutaneous with 25 mu g/kg/day of recombinant human G-CSF for 7 days, and the ones in the control group with 0.9% sodium chloride. Rats were sacrificed 3 weeks after surgery and then radiological, histological and biomechanical evaluations were performed. Biomechanical tests were performed at the Middle East Technical University, Ankara, Turkey. Results: The median radiographic scores for the control group were calculated as 4.1, and 6.1 for the G-CSF group (p = 0.016). Cortex remodeling, callus formation, bone union and marrow changes values did not differ significantly (p > 0.05). Mechanical parameter (mean max-Load) values for the control group were found to be 24.0 +/- 3.0 N, and 241.5 +/- 75.7 N for the G-CSF group (p = 0.001). Conclusions: We found that G-CSF has an important effect on fracture healing. However, this effect requires further study.en_US
dc.identifier.endpage1254en_US
dc.identifier.issn0379-5284
dc.identifier.issue8en_US
dc.identifier.pmid16127524en_US
dc.identifier.scopus2-s2.0-24744466548en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1250en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13854
dc.identifier.volume26en_US
dc.identifier.wosWOS:000231898100017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrowth-Factorsen_US
dc.subjectNeutropeniaen_US
dc.subjectChemotherapyen_US
dc.subjectMacrophageen_US
dc.titleEffects of human granulocyte-colony stimulating factor on fracture healing in ratsen_US
dc.typeArticleen_US

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