Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio levels are associated with keratoconus

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dc.contributor.authorElbeyli, Ahmet
dc.contributor.authorKurtul, Bengi Ece
dc.date.accessioned2024-09-18T20:27:59Z
dc.date.available2024-09-18T20:27:59Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to assess the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with keratoconus (KC). Methods: A total of 42 patients with KC (KC group) and 42 age- and sex-matched healthy subjects (control group) were included into this cross sectional study. Complete blood count parameters were assayed. SII, NLR, red cell distribution width (RDW), and PLR values were calculated. The SII value was calculated as follows: platelet count x (neutrophil/lymphocyte). Results: SII, NLR, RDW, and PLR values were significantly higher in KC group compared to control group [709 +/- 236 vs. 418 +/- 117 (P < 0.001), 2.5 +/- 0.8 vs. 1.76 +/- 0.3 (P < 0.001), 14.3 +/- 1.6% vs. 12.9 +/- 0.54% (P < 0.001), and 143 +/- 36 vs. 106 +/- 23 (P < 0.001), respectively]. Using the receiver operating characteristics (ROC) curve analysis to predict KC, the highest area under the curve (AUC) was determined SII (0.846 for SII, 0.778 for NLR, and 0.796 for PLR). Conclusion: SII, NLR, RDW, and PLR levels were significantly increased in patients with KC. This study supports the idea that several inflammatory pathways may play important role in the pathogenesis of this disorder. SII may be much better marker than NLR and PLR for predicting the inflammatory status of the disease.en_US
dc.identifier.doi10.4103/ijo.IJO_3011_20
dc.identifier.endpage1729en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.issue7en_US
dc.identifier.pmid34146015en_US
dc.identifier.scopus2-s2.0-85108672485en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1725en_US
dc.identifier.urihttps://doi.org/10.4103/ijo.IJO_3011_20
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10655
dc.identifier.volume69en_US
dc.identifier.wosWOS:000691995400018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectkeratoconusen_US
dc.subjectneutrophil/lymphocyte ratioen_US
dc.subjectplatelet/lymphocyte ratioen_US
dc.subjectred cell distribution widthen_US
dc.subjectsystemic immune-inflammation indexen_US
dc.titleSystemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio levels are associated with keratoconusen_US
dc.typeArticleen_US

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