Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin

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dc.authoridSERVI, Kadir/0000-0001-5610-9505
dc.authoridGULCU BULMUS, Funda/0000-0002-2514-4559
dc.contributor.authorBulmus, Funda Gulcu
dc.contributor.authorSakin, Fatih
dc.contributor.authorTurk, Gaffari
dc.contributor.authorSonmez, Mustafa
dc.contributor.authorServi, Kadir
dc.date.accessioned2024-09-18T20:13:39Z
dc.date.available2024-09-18T20:13:39Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of curcumin (CUR) on antioxidant status, body weight (BW) gains, and some reproductive parameters in male rats exposed to subchronic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Thirty-two rats were divided into four groups. The first group was kept as control. The second group (TCDD group) was given TCDD at a dose of 50ngkg(-1) BW per day; the third group (CUR group) was treated with CUR at a dose of 80mgkg(-1) BW per day. The fourth group (TCDD + CUR group) was given TCDD and CUR at the same doses simultaneously. Malondialdehyde (MDA) levels were significantly increased in the TCDD group. In addition, TCDD exposure decreased liver superoxide dismutase (SOD) activity, catalase (CAT) activities of kidney and brain, glutathione peroxidase (GSH-Px) activities of liver, kidney, and brain, and glutathione levels of liver, kidney, and heart. However, CUR treatment with TCDD exposure decreased MDA levels in all tissues and increased SOD activities of liver, kidney, and brain, CAT activity of heart, and GSH-Px activities of heart and brain. TCDD caused a decrease in BW gain, and CUR partially eliminated this effect of TCDD. In addition, while reproductive organ weights, sperm concentration, and sperm motility tended to decrease with TCDD exposure, these effects tended to be close to normal levels by CUR treatment. In conclusion, CUR was seen to be effective in the treatment and prevention of toxicity induced by subchronic TCDD exposure.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBTAK) [106O828]en_US
dc.description.sponsorshipThe authors acknowledge financial support from the Scientific and Technological Research Council of Turkey (TUBTAK) (project number: 106O828).en_US
dc.identifier.doi10.1080/02772248.2013.829061
dc.identifier.endpage1029en_US
dc.identifier.issn0277-2248
dc.identifier.issn1029-0486
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84887117230en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1019en_US
dc.identifier.urihttps://doi.org/10.1080/02772248.2013.829061
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9307
dc.identifier.volume95en_US
dc.identifier.wosWOS:000326309900014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicological and Environmental Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcurcuminen_US
dc.subject2,3,7,8-tetrachlorodibenzo-p-dioxinen_US
dc.subjectantioxidant statusen_US
dc.subjectbody weight gainen_US
dc.subjectreproductive parametersen_US
dc.titleProtective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxinen_US
dc.typeArticleen_US

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