Histopathological changes of cervical tissue in women with systemic sclerosis

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dc.contributor.authorEvruke, C
dc.contributor.authorErtunc, D
dc.contributor.authorDoran, F
dc.contributor.authorOzbek, S
dc.contributor.authorKadayifci, O
dc.date.accessioned2024-09-18T20:29:47Z
dc.date.available2024-09-18T20:29:47Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSystemic sclerosis is a connective tissue disease that can affect almost any organ of the body. The clinical aspects of systemic sclerosis on the reproductive system have been studied in large series, and an increased rate of cesarean section has been reported. For this reason, in the present study the histopathological features of cervical specimens of hysterectomyzed women with systemic sclerosis were evaluated. An increased frequency of vascular and stromal abnormalities in cervical specimens of women with systemic sclerosis were observed. Vascular medial hypertrophy, intimal thickening, and fibrosis were more often encountered in the cervical specimens of the patients with systemic sclerosis. Some of the histopathological features also showed correlation with the clinical profile of the disease. The patients with vascular medial hypertrophy in their cervical specimens were older, had a higher Rodnan score, and had longer duration of the disease. In contrast to vascular medial hypertrophy, periadventitial edema was found in the cervical specimens of the patients who were younger, had a lower Rodnan score, and had shorter duration of the disease. It was concluded that the problems that are seen in common obstetric and gynecological practices in patients with systemic sclerosis may be explained by these tissue abnormalities.en_US
dc.identifier.doi10.1111/j.1440-1827.2004.01749.x
dc.identifier.endpage764en_US
dc.identifier.issn1320-5463
dc.identifier.issn1440-1827
dc.identifier.issue10en_US
dc.identifier.pmid15482565en_US
dc.identifier.scopus2-s2.0-7544229339en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage759en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1827.2004.01749.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11061
dc.identifier.volume54en_US
dc.identifier.wosWOS:000224398000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPathology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmedial hypertrophyen_US
dc.subjectsystemic sclerosisen_US
dc.subjectuterine cervixen_US
dc.subjectvasculitisen_US
dc.titleHistopathological changes of cervical tissue in women with systemic sclerosisen_US
dc.typeArticleen_US

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