Genetic variations of renin-angiotensin and fibrinolytic systems and susceptibility to coronary artery disease: a population genetics perspective

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dc.contributor.authorBayramoglu, Aysegul
dc.contributor.authorBayramoglu, Gokhan
dc.contributor.authorUrhan Kucuk, Meral
dc.contributor.authorGuler, Halil, I
dc.contributor.authorArpaci, Abdullah
dc.date.accessioned2024-09-18T20:13:22Z
dc.date.available2024-09-18T20:13:22Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: Genetic predisposition is an important risk factor in coronary artery disease (CAD).This study was conducted to determine the polymorphism frequencies of the plasminogen activator inhibitor-1(PAI-1) gene 4G/5G, angiotensin-converting enzyme (ACE) gene I/D, and angiotensin II type 1 receptor (AT1) gene A1166C genotypes and to examine the role of these polymorphisms in CAD. METHODS: Genomic DNAs obtained from 260 subjects (130 CAD patients and 130 control) were used in the study. ACE I/D and PAI-1 4G/5G polymorphism genotypes were determined using polymerase chain reaction (PCR) and electrophoresis. AT-1 A1166C polymorphism was determined using the PCR, restriction fragment length polymorphism (RFLP) and electrophoresis. The products amplified from AT1 gene by PCR were cut with HindIII restriction endonuclease and then analyzed by 2% agarose gel electrophoresis. The results were statistically analyzed with the chi-square test, Mann-Whitney U test, and independent two-sample t-test. RESULTS: Allele frequencies showed statistically significant differences between the patient and control groups. There was no statistically significant difference in ACEI/D genotype frequencies between the twogroups. Likewise, no statistically significant difference was found in the AT1 A1166C genotype frequencies; however, a statistically significant difference was found in allele frequencies. The PAI-1 4G/5G genotype frequency was significantly higher in the patient group. CONCLUSIONS: While there is a relationship between of PAI-1 gene 4G/5G polymorphism and CAD, ACE gene I/D and AT1 gene A1166C polymorphisms are not related. PAI-1 gene homozygous genotypes may be considered as a prognostic marker for CAD patients.en_US
dc.description.sponsorshipResearch Foundation of the University of Artvin Coruh, Turkey [2013.M15.02.03, 2013.M15.02.02]en_US
dc.description.sponsorshipThe study was funded by Research Foundation of the University of Artvin Coruh, Turkey (Grant N. 2013.M15.02.03, 2013.M15.02.02).en_US
dc.identifier.doi10.23736/S2724-5683.20.05212
dc.identifier.endpage24en_US
dc.identifier.issn2724-5683
dc.identifier.issn2724-5772
dc.identifier.issue1en_US
dc.identifier.pmid32989965en_US
dc.identifier.scopus2-s2.0-85126072866en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage16en_US
dc.identifier.urihttps://doi.org/10.23736/S2724-5683.20.05212
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9127
dc.identifier.volume70en_US
dc.identifier.wosWOS:000969320000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Cardiology and Angiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectGeneticsen_US
dc.subjectCardiologyen_US
dc.titleGenetic variations of renin-angiotensin and fibrinolytic systems and susceptibility to coronary artery disease: a population genetics perspectiveen_US
dc.typeArticleen_US

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