Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basin

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dc.authoridRosati, Sergio/0000-0002-8315-0316
dc.authoridPuggioni, Giantonella/0000-0001-9013-8203
dc.authoridBertolotti, Luigi/0000-0001-7931-4528
dc.authoridMUZ, Dilek/0000-0001-9358-8103
dc.authoridMazzei, Maurizio/0000-0003-3797-8320
dc.contributor.authorBertolotti, L.
dc.contributor.authorMazzei, M.
dc.contributor.authorPuggioni, G.
dc.contributor.authorCarrozza, M. L.
dc.contributor.authorGiudici, S. Dei
dc.contributor.authorMuz, D.
dc.contributor.authorJuganaru, M.
dc.date.accessioned2024-09-18T21:05:12Z
dc.date.available2024-09-18T21:05:12Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSmall ruminant lentiviruses (SRLVs) represent a group of viruses infecting sheep and goats worldwide. Despite the high heterogeneity of genotype A strains, which cluster into as many as ten subtypes, genotype B was believed to be less complex and has, so far, been subdivided into only two subtypes. Here, we describe two novel full-length proviral sequences isolated from Sarda sheep in two Italian regions. Genome sequence as well as the main linear epitopes clearly placed this cluster into genotype B. However, owing to long-standing segregation of this sheep breed, the genetic distances that are clearly >15% with respect to B1 and B2 subtypes suggest the designation of a novel subtype, B3. Moreover the close relationship with a gag sequence obtained from a Turkish sheep adds new evidence to historical data that suggest an anthropochorous dissemination of hosts (small ruminants) and their pathogens (SRLV) during the colonization of the Mediterranean from the Middle East.en_US
dc.description.sponsorshipItalian Ministry of Health Ricerca finalizzata; Italian Ministry of Instruction, University and Research; Piedmont Regionen_US
dc.description.sponsorshipThe plasmids used in this study, pCMVlcn and pCAEV-AP were kindly provided by Dr I. Hotzel. This work has been partially funded by the Italian Ministry of Health Ricerca finalizzata 2006 DIAGNOVA, Italian Ministry of Instruction, University and Research PRIN 2008 and Piedmont Region 2008 Ricerca Sanitaria Finalizzata 2008.en_US
dc.identifier.doi10.1099/vir.0.032334-0
dc.identifier.endpage1929en_US
dc.identifier.issn0022-1317
dc.identifier.issn1465-2099
dc.identifier.pmid21562119en_US
dc.identifier.scopus2-s2.0-79960346125en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1923en_US
dc.identifier.urihttps://doi.org/10.1099/vir.0.032334-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13446
dc.identifier.volume92en_US
dc.identifier.wosWOS:000293488800022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMicrobiology Socen_US
dc.relation.ispartofJournal of General Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLong Terminal Repeaten_US
dc.subjectVisna Virusen_US
dc.subjectMixed Flocksen_US
dc.subjectSequenceen_US
dc.subjectGoatsen_US
dc.subjectSheepen_US
dc.subjectHeterogeneityen_US
dc.subjectTransmissionen_US
dc.subjectTropismen_US
dc.subjectCaeven_US
dc.titleCharacterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basinen_US
dc.typeArticleen_US

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