Investigation of antioxidant enzyme polymorphism in chronic obstructive pulmonary disease patients

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dc.authorscopusid6603061715
dc.authorscopusid8608387300
dc.authorscopusid57202544792
dc.authorscopusid57202546159
dc.authorscopusid55507626600
dc.authorscopusid6602143517
dc.contributor.authorArpaci, Abdullah
dc.contributor.authorYalin, Serap
dc.contributor.authorTaskin, Devrim
dc.contributor.authorFakioglu, Fusun
dc.contributor.authorUlutas, Kemal Turker
dc.contributor.authorComelekoglu, Ulku
dc.date.accessioned2024-09-19T15:43:34Z
dc.date.available2024-09-19T15:43:34Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Antioxidant system enzyme activity and polymorphism were investigated in Chronic Obstructive Pulmonary Disease (COPD), which is increasingly prevalent both in the world and our country. Methods: Malondialdehyde (MDA) was measured to determine lipid peroxidation, while Catalase (CAT), Paraoxonase (PON) and Superoxide Dismutase (SOD) enzyme activities were measured to determine antioxidant activity. For molecular analysis, leukocytes were separated and DNA was isolated from cell nuclei and the targeted genes were amplified by using PCR. Targeted base changes were detected by the restriction fragment length polymorphism technique. Results: Evaluating CAT polymorphism, there was 35 (35%) TT, 52 (52%) TC and 13 (13%) CC genotypes in the control group, as 38 (38%) TT, 40 (40%) TC and 22 (22%) CC genotypes in the patient. In SOD, there were 32 (32%) TT, 49 (49%) TC, 19 (19%) CC genotypes in the control group, as 34 (34%) TT, 50 (50%) TC and 16 (16%) CC genotypes in the patient. In PON55, there were 50 (50%) LL, 38 (38%) LM, 12 (12%) MM genotypes in the control group, as 39 (39%) LL, 49 (49%) LM and 12 (12%) MM genotypes in the patient. In PON192, there were 77 (77%) QQ, 21 (21%) QR, 2 (2%) RR genotypes in the control group, as 66 (66%) QQ, 29 (49%) QR, 5 (5%) RR genotypes in the patient. There was no significant difference in genotype distribution for CAT, SOD, PON55 and PON192 polymorphisms between groups. Conclusion: In conclusion, COPD patients were found to have a deficiency in the antioxidant defense system. This will lead to the development of oxidative stress in patients and the complications of COPD. There was no polymorphic difference between the control group and South African patients living in Adiyaman in COPD whose genetic characteristics were not fully explained. © 2018, Scientific Publishers of India. All rights reserved.en_US
dc.identifier.doi10.4066/biomedicalresearch.29-17-3854
dc.identifier.endpage1913en_US
dc.identifier.issn0970-938X
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85048712244en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1906en_US
dc.identifier.urihttps://doi.org/10.4066/biomedicalresearch.29-17-3854
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14422
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectEnzyme polymorphismen_US
dc.titleInvestigation of antioxidant enzyme polymorphism in chronic obstructive pulmonary disease patientsen_US
dc.typeArticleen_US

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