The Effects of Interferon ?2b on Chemically-induced Peritoneal Fibrosis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Rats

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dc.contributor.authorUcar, E.
dc.contributor.authorBorazan, A.
dc.contributor.authorSemerci, E.
dc.contributor.authorBinici, D. N.
dc.contributor.authorYaldiz, M.
dc.contributor.authorAysal, A.
dc.contributor.authorAltug, E.
dc.date.accessioned2024-09-18T20:54:10Z
dc.date.available2024-09-18T20:54:10Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study investigated the effect of interferon alpha 2b on chlorhexidine gluconate (CH)-induced peritoneal fibrosis (PF) in rats and assessed peritoneal tissue levels of metalloproteinase (MMP)-2 and tissue inhibitors of metalloproteinases (TIMP)-2. Wistar albino rats (n = 8 per group) were treated as follows: control group, 3 ml/day of 0.9% saline intraperitoneally for 28 days; CH group, 0.1% CH (200 g [3 ml]/day) in 15% ethanol and 0.9% saline intra-peritoneally for 28 days; CH + interferon (IFN) group, CH (as above) plus pegylated IFN-alpha 2b 1.5 mu g/kg per week subcutaneously on days 0, 7, 14, 21 and 28; IFN group, pegylated IFN-alpha 2b (as above). Parietal peritoneum samples were obtained from the left anterior abdominal wall after 35 days. Parietal thickness, degree of vascular proliferation and inflammation, and MMP-2 and TIMP-2 levels were determined. The mean peritoneal thicknesses of the control, CH, CH + IFN and IFN groups were 7.02 +/- 3.89, 156.86 +/- 29.13, 59.88 +/- 22.1, 9.27 +/- 2.03 mu m, respectively. Pegylated IFN-alpha 2b decreased CH-induced expression of MMP-2 in the parietal peritoneum, but had no effect on TIMP-2 levels. Further studies are needed to determine the optimal dosage and duration for pegylated IFN-alpha 2b treatment.en_US
dc.identifier.doi10.1177/147323001003800121
dc.identifier.endpage194en_US
dc.identifier.issn0300-0605
dc.identifier.issue1en_US
dc.identifier.pmid20233528en_US
dc.identifier.scopus2-s2.0-77749298704en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage187en_US
dc.identifier.urihttps://doi.org/10.1177/147323001003800121
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11636
dc.identifier.volume38en_US
dc.identifier.wosWOS:000276789900021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPERITONEAL FIBROSISen_US
dc.subjectINTERFERON-alpha 2B (IFN-alpha 2B)en_US
dc.subjectCHLORHEXIDINE GLUCONATEen_US
dc.subjectRATSen_US
dc.subjectMATRIX METALLOPROTEINASE-2 (MMP-2)en_US
dc.subjectTISSUE INHIBITORS METALLOPROTEINASE-2 (TIMP-2)en_US
dc.subjectPARIETAL THICKENINGen_US
dc.titleThe Effects of Interferon ?2b on Chemically-induced Peritoneal Fibrosis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Ratsen_US
dc.typeArticleen_US

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