Prognostic Role of the Pectoralis Musculature in Patients with COVID-19. A Multicenter Study

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dc.authoridKorkmaz, Inan/0000-0001-6820-8199
dc.authoridKardas, Hakan/0000-0002-2963-2138
dc.contributor.authorSurov, Alexey
dc.contributor.authorKardas, Hakan
dc.contributor.authorBesutti, Giulia
dc.contributor.authorPellegrini, Massimo
dc.contributor.authorOttone, Marta
dc.contributor.authorOnur, Mehmet Ruhi
dc.contributor.authorAtak, Firat
dc.date.accessioned2024-09-18T20:13:27Z
dc.date.available2024-09-18T20:13:27Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractRationale and Objectives: To evaluate the impact of low skeletal muscle mass in patients with COVID-19 on relevant outcomes like 30-day mortality, need for intubation and need for intensive care unit admission.Materials and Methods: For this study, data from six centers were acquired. The acquired sample comprises 1138 patients. There were 547 women (48.1%) and 591 men (51.9%) with a mean age of 54.5 +/- 18.8 years; median age, 55 years; range, 18-84 years). In every case, thoracic CT without intravenous application of contrast medium was performed. The following parameters of the pectoralis muscles were estimated: muscle area as a sum of the bilateral areas of the pectoralis major and minor muscles, muscle density, muscle index (PMI) (pectoralis muscle area divided by the patient's body height square) as a ratio pectoralis major and minor muscles divided by the patient's body height2, and muscle gauge as PMI x muscle density. Results: Overall, 220 patients (19.33%) were admitted to the intensive care unit. In 171 patients (15.03%), mechanical lung ventilation was performed. Finally, 154 patients (13.53%) died within the observation time of 30-day. All investigated parameters of pectoralis muscle were lower in the patients with unfavorable courses of Covid-19. All pectoralis muscle parameters were associated with 30-day mortality in multivariate analyses adjusted for age and sex: pectoralis muscle area, HR = 0.93 CI 95% (0.91-0.95) p < 0.001; pectoralis muscle den-sity, HR = 0.94 CI 95% (0.93-0.96) p < 0.001; pectoralis muscle index, HR = 0.79 CI 95% (0.75-0.85) p < 0.001, pectoralis muscle gauge, HR = 0.995 CI 95% (0.99-0.996) p < 0.001.Conclusion: in COVID-19, survivors have larger areas and higher index, gauge and density of the pectoralis muscles in comparison to nonsurvivors. However, the analyzed muscle parameters cannot be used for prediction of disease courses.en_US
dc.description.sponsorshipGerman Federal Ministry of Education and Research (BMBF), University Medicine Network (Project RACOON) [01KX2021]en_US
dc.description.sponsorshipThis research was supported by the German Federal Ministry of Education and Research (BMBF) as part of the University Medicine Network (Project RACOON, 01KX2021) .en_US
dc.identifier.doi10.1016/j.acra.2022.05.003
dc.identifier.endpage82en_US
dc.identifier.issn1076-6332
dc.identifier.issn1878-4046
dc.identifier.issue1en_US
dc.identifier.pmid35667979en_US
dc.identifier.scopus2-s2.0-85131354309en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1016/j.acra.2022.05.003
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9201
dc.identifier.volume30en_US
dc.identifier.wosWOS:000897902200010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAcademic Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectsarcopeniaen_US
dc.subjectsurvivalen_US
dc.titlePrognostic Role of the Pectoralis Musculature in Patients with COVID-19. A Multicenter Studyen_US
dc.typeArticleen_US

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