The effect of positive airway pressure therapy on intraocular pressure and retina in severe obstructive apnea syndrome

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dc.authoridcakmak, ayse idil/0000-0003-4377-7314
dc.contributor.authorDikmen, Nursel
dc.contributor.authorCakmak, Ayse Idil
dc.contributor.authorUrfalioglu, Selma
dc.date.accessioned2024-09-18T20:52:49Z
dc.date.available2024-09-18T20:52:49Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTo identify and compare changes in intraocular pressure (IOP), macular, and peripapillary retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) measurements before and after 3 months of positive airway pressure (PAP) therapy in patients with severe obstructive sleep apnea syndrome (OSAS). Twenty-five patients diagnosed with severe OSAS in the neurology sleep outpatient clinic were included in the study. Ophthalmologic examinations were performed at the time of diagnosis and after 3 months of PAP therapy. Statistical analysis of comparisons of pre-treatment and post-treatment measurements of IOP and OCT was performed. Before the PAP therapy, the correlations between central corneal thickness (CCT), body mass index (BMI), OCT, IOP, and sleep parameters were statistically analyzed. Compared to the pre-treatment measurements at the time of diagnosis, post-treatment measurements showed insignificant decrease in IOP, significant increase in mean macular thickness and significant thinning in superior nasal RNFL. There was no correlation found between pre-treatment measurements including IOP, OCT, CCT, BMI, and sleep parameters. The effect of intermittent hypoxia and hypercapnia on the IOP and macula may be reversible in severe OSAS patients receiving 3 months of PAP therapy, but the reversibility of the neurodegenerative effects of OSAS on RNFL with this treatment seems controversial. OCT can be considered to be a promising technique for monitoring disease progression under PAP therapy in patients with severe OSAS.en_US
dc.identifier.doi10.1007/s41105-021-00366-1
dc.identifier.endpage273en_US
dc.identifier.issn1446-9235
dc.identifier.issn1479-8425
dc.identifier.issue2en_US
dc.identifier.pmid38469251en_US
dc.identifier.scopus2-s2.0-85123178744en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1007/s41105-021-00366-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11429
dc.identifier.volume20en_US
dc.identifier.wosWOS:000744370100002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofSleep and Biological Rhythmsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectHypoxiaen_US
dc.subjectHypercapniaen_US
dc.subjectGlaucomaen_US
dc.subjectOptical coherence tomographyen_US
dc.titleThe effect of positive airway pressure therapy on intraocular pressure and retina in severe obstructive apnea syndromeen_US
dc.typeArticleen_US

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