The impact of hepatitis C viremia status on lung functions in chronic hepatitis c patients

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dc.authoridBal, Tayibe/0000-0002-5315-122X
dc.authoridBabayigit, Cenk/0000-0001-9760-6081
dc.contributor.authorBal, Tayibe
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorBabayigit, Cenk
dc.contributor.authorYumer, Yusuf
dc.contributor.authorSahin, Selma Ilkay
dc.date.accessioned2024-09-18T20:08:25Z
dc.date.available2024-09-18T20:08:25Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Previous trials have investigated the effect of hepatitis C on lung functions; however, the role of viral load levels is unclear. The aim of this study was to investigate the effect of HCV viremia status on lung functions. Methods: This study was in 60 patients with chronic hepatitis C (CHC). Patients were classified into three groups (non-viremic, low-viremic and high-viremic) based on serum HCV RNA levels. Spirometric parameters (FEV1, FVC, FEV1/FVC) and the proportion of patients with spirometric abnormalities were compared between three groups. Results: High-viremic and low-viremic patients showed a significantly higher prevalence of spirometric abnormality than observed in non-viremic patients (p=0.02). Moreover, there was a significant moderate correlation between viremia level and the percentage of spirometric abnormalities (Cramer's U value=0.452, p=0.002). High-viremic patients were 14.2 times more likely to exhibiting pulmonary dysfunction than non-viremic patients. Additionally, spirometric parameters FEV1 and FVC were significantly reduced in high-viremic and low-viremic patients compared to those in non-viremic patients (p=0.013 and p<0.001 respectively). Conclusion: These results indicate that persistent HCV infection may be associated with reduced pulmonary functions, especially in patients with high viremia levels. Therefore, these patients should be carefully monitored for lung function.en_US
dc.identifier.doi10.4314/ahs.v19i2.21
dc.identifier.endpage1992en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue2en_US
dc.identifier.pmid31656481en_US
dc.identifier.scopus2-s2.0-85071460220en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1988en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v19i2.21
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8820
dc.identifier.volume19en_US
dc.identifier.wosWOS:000482191800021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic hepatitis C infectionen_US
dc.subjectviremiaen_US
dc.subjectlung function testsen_US
dc.titleThe impact of hepatitis C viremia status on lung functions in chronic hepatitis c patientsen_US
dc.typeArticleen_US

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