Association of insulin resistance, viral load, and adipokine levels with liver histology in patients with chronic hepatitis C: an observational, multicenter study in Turkey

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dc.contributor.authorAksu, Hasan S. Zeki
dc.contributor.authorKurtaran, Behice
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorNamiduru, Mustafa
dc.contributor.authorInkaya, Ahmet C.
dc.contributor.authorKandemir, Ozlem
dc.contributor.authorDoran, Figen
dc.date.accessioned2024-09-18T19:50:23Z
dc.date.available2024-09-18T19:50:23Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective To evaluate the association of insulin resistance (IR), viral load, and adipokine levels with liver histology in patients with chronic hepatitis C (CHC). Patients and methods In this noninterventional, multicenter study carried out at 11 infectious diseases clinics in Turkey, 103 CHC patients [mean (SD) age: 50.2 (11.0) years, 60 (58.3%) women] planned to be treated by ribavirin and peginterferon-alpha 2a were included. Data on hepatic fibrosis and steatosis, IR, viral load, and hepatitis C virus-RNA genotyping, adipokine, and cytokine levels were collected. Results The mean (SD) Knodell score was 8.1 (3.6); grade I steatosis was evident in 46 (44.7%) patients and IR was identified in 56 (54.9%). There was a significant positive correlation of the homeostasis model assessment-IR index with Knodell fibrosis (r=0.235; P=0.027) and hepatic steatosis (r=0.435; P<0.001). There was a significant positive correlation of leptin levels with Knodell fibrosis (r=0.265; P=0.013) and hepatic activity index (r=0.218; P=0.041). Hepatic steatosis was correlated negatively with adiponectin (r=-0.320; P=0.001) and positively with leptin (r=-0.368; P<0.001) levels. Logistic regression analysis showed that increase in age [odds ratio (OR), 1.056; 95% confidence interval (CI), 1.005-1.110; P=0.030] was the only significant predictor of hepatic fibrosis (OR, 1.056; 95% CI, 1.005-1.110; P=0.030), whereas increase in age (OR, 1.066; 95% CI, 1.006-1.130; P=0.030), the presence of IR (OR, 5.621; 95% CI, 1.547-20.425; P=0.009), and decrease in adiponectin levels (OR, 0.808; 95% CI, 0.682-0.957; P=0.013) were the significant predictors of hepatic steatosis. Conclusion Our findings indicate a significant relationship of hepatic fibrosis and hepatic steatosis with IR and leptin levels, but not with the viral load in Turkish patients with CHC. Eur J Gastroenterol Hepatol 24:1393-1399 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.description.sponsorshipRoche Pharmaceuticals, Istanbul, Turkeyen_US
dc.description.sponsorshipThe study is granted by Roche Pharmaceuticals, Istanbul, Turkey. The authors thank Associate Professor Murat Sert, MD, for his valuable expertise on insulin resistance during the planning phase of the study, Professor Figen Doran, MD, for evaluating the biopsy samples from the Departments of Endocrinology and Pathology, Faculty of Medicine, Cukurova University, Adana, respectively, and also Professor Sule Oktay, MD, PhD, and Cagla Isman, MD, from KAPPA Consultancy Training Research Ltd (Istanbul, Turkey) for their support in manuscript preparation.en_US
dc.identifier.doi10.1097/MEG.0b013e3283585863
dc.identifier.endpage1399en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue12en_US
dc.identifier.pmid23114743en_US
dc.identifier.scopus2-s2.0-84869474706en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1393en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0b013e3283585863
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7406
dc.identifier.volume24en_US
dc.identifier.wosWOS:000311084100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadipokinesen_US
dc.subjectchronic hepatitis Cen_US
dc.subjecthepatic steatosisen_US
dc.subjectinsulin resistanceen_US
dc.subjectviral loaden_US
dc.titleAssociation of insulin resistance, viral load, and adipokine levels with liver histology in patients with chronic hepatitis C: an observational, multicenter study in Turkeyen_US
dc.typeArticleen_US

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