Synthetic (JWH-018) cannabinoid-induced immune suppression of T-lymphocytes in spleen tissue

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dc.contributor.authorMutluay, Duygu
dc.contributor.authorTenekeci, Gozde Yucel
dc.contributor.authorAmbarcioglu, Pinar
dc.contributor.authorUslu, Sema
dc.date.accessioned2024-09-18T20:28:13Z
dc.date.available2024-09-18T20:28:13Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSynthetic cannabinoid JWH-018 is a potent cannabinoid receptor agonist that plays a role in the immune system. It is a substance whose consumption is rising globally. While numerous studies have explored the impact of cannabinoids on immunity, limited information exists regarding the immunosuppressive effects on T cells within spleen tissue. Hence, this study aims to investigate the effects of JWH-018 on CD cells in the spleen. Thirty male CD -1 mice were categorized into three groups: the sham group (G1), the ethanol group (G2), and the JWH-018 group (G3). These animals received treatments of saline, ethanol, and JWH-018 (0.3 mg/kg) respectively for 9 consecutive days, after which all groups were sacrificed on day 2. Our findings revealed a statistically significant weight loss in G3 compared to G2, whereas a weight gain was observed in G1 and G2. Except for one animal, no significant histopathological changes were detected in the control and treatment groups. However, the treatment group exhibited a notable decrease in white pulp size. Moreover, we demonstrated that JWH-018 can induce apoptosis, leading to a decrease in CD3, CD4, and CD8 expression in T cells, which may result in immunosuppression in vivo in T lymphocytes. These results collectively suggest that exposure to JWH-018 can lead to the suppression of CD3, CD4, and CD8 expression by inducing apoptosis. Consequently, the results of this study show that JWH-018 may have a potential for use as an immunosuppressant in various medical conditions, particularly in autoimmune diseases or situations requiring immune system suppression.en_US
dc.identifier.doi10.21521/mw.6860
dc.identifier.endpage167en_US
dc.identifier.issn0025-8628
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85186679784en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.21521/mw.6860
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10798
dc.identifier.volume80en_US
dc.identifier.wosWOS:001175877200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolish Soc Veterinary Sciences Editorial Officeen_US
dc.relation.ispartofMedycyna Weterynaryjna-Veterinary Medicine-Science and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectJWH-018en_US
dc.subjectimmunityen_US
dc.subjectimmunosuppressionen_US
dc.subjectspleenen_US
dc.subjectsynthetic cannabinoiden_US
dc.titleSynthetic (JWH-018) cannabinoid-induced immune suppression of T-lymphocytes in spleen tissueen_US
dc.typeArticleen_US

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